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Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila

BACKGROUND: The BLM DNA helicase plays a vital role in maintaining genome stability. Mutations in BLM cause Bloom syndrome, a rare disorder associated with cancer predisposition and premature aging. Humans and mice with blm mutations have increased frequencies of spontaneous mutagenesis, but the mol...

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Detalles Bibliográficos
Autores principales:	Garcia, Ana Maria, Salomon, Robert N, Witsell, Alice, Liepkalns, Justine, Calder, R Brent, Lee, Moonsook, Lundell, Martha, Vijg, Jan, McVey, Mitch
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334616/ https://www.ncbi.nlm.nih.gov/pubmed/22183041 http://dx.doi.org/10.1186/gb-2011-12-12-r121

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