Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses

Methylation of histones is central to chromatin regulation, and thus novel mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here, we identify Set5 as the first histone H4 methyltransferase in budding yeast, which monomethylates the important H4...

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Autores principales: Green, Erin M., Mas, Gloria, Young, Nicolas L., Garcia, Benjamin A., Gozani, Or
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334815/
https://www.ncbi.nlm.nih.gov/pubmed/22343720
http://dx.doi.org/10.1038/nsmb.2252
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author Green, Erin M.
Mas, Gloria
Young, Nicolas L.
Garcia, Benjamin A.
Gozani, Or
author_facet Green, Erin M.
Mas, Gloria
Young, Nicolas L.
Garcia, Benjamin A.
Gozani, Or
author_sort Green, Erin M.
collection PubMed
description Methylation of histones is central to chromatin regulation, and thus novel mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here, we identify Set5 as the first histone H4 methyltransferase in budding yeast, which monomethylates the important H4 lysine residues 5, 8 and 12. Set5’s enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses.
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spelling pubmed-33348152012-09-01 Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses Green, Erin M. Mas, Gloria Young, Nicolas L. Garcia, Benjamin A. Gozani, Or Nat Struct Mol Biol Article Methylation of histones is central to chromatin regulation, and thus novel mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here, we identify Set5 as the first histone H4 methyltransferase in budding yeast, which monomethylates the important H4 lysine residues 5, 8 and 12. Set5’s enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses. 2012-02-19 /pmc/articles/PMC3334815/ /pubmed/22343720 http://dx.doi.org/10.1038/nsmb.2252 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Green, Erin M.
Mas, Gloria
Young, Nicolas L.
Garcia, Benjamin A.
Gozani, Or
Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses
title Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses
title_full Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses
title_fullStr Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses
title_full_unstemmed Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses
title_short Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses
title_sort methylation of h4 lysines 5, 8 and 12 by yeast set5 calibrates chromatin stress responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334815/
https://www.ncbi.nlm.nih.gov/pubmed/22343720
http://dx.doi.org/10.1038/nsmb.2252
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