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Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation
Human papillomaviruses (HPVs) target the stratified epidermis, and can causes diseases ranging from benign condylomas to malignant tumors. Infections of HPVs in the genital tract are among the most common sexually transmitted diseases, and a major risk factor for cervical cancer. The virus targets e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334820/ https://www.ncbi.nlm.nih.gov/pubmed/22536200 http://dx.doi.org/10.3389/fmicb.2012.00152 |
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author | Kajitani, Naoko Satsuka, Ayano Kawate, Akifumi Sakai, Hiroyuki |
author_facet | Kajitani, Naoko Satsuka, Ayano Kawate, Akifumi Sakai, Hiroyuki |
author_sort | Kajitani, Naoko |
collection | PubMed |
description | Human papillomaviruses (HPVs) target the stratified epidermis, and can causes diseases ranging from benign condylomas to malignant tumors. Infections of HPVs in the genital tract are among the most common sexually transmitted diseases, and a major risk factor for cervical cancer. The virus targets epithelial cells in the basal layer of the epithelium, while progeny virions egress from terminally differentiated cells in the cornified layer, the surface layer of the epithelium. In infected basal cells, the virus maintains its genomic DNA at low-copy numbers, at which the viral productive lifecycle cannot proceed. Progression of the productive lifecycle requires differentiation of the host cell, indicating that there is tight crosstalk between viral replication and host differentiation programs. In this review, we discuss the regulation of the HPV lifecycle controlled by the differentiation program of the host cells. |
format | Online Article Text |
id | pubmed-3334820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33348202012-04-25 Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation Kajitani, Naoko Satsuka, Ayano Kawate, Akifumi Sakai, Hiroyuki Front Microbiol Microbiology Human papillomaviruses (HPVs) target the stratified epidermis, and can causes diseases ranging from benign condylomas to malignant tumors. Infections of HPVs in the genital tract are among the most common sexually transmitted diseases, and a major risk factor for cervical cancer. The virus targets epithelial cells in the basal layer of the epithelium, while progeny virions egress from terminally differentiated cells in the cornified layer, the surface layer of the epithelium. In infected basal cells, the virus maintains its genomic DNA at low-copy numbers, at which the viral productive lifecycle cannot proceed. Progression of the productive lifecycle requires differentiation of the host cell, indicating that there is tight crosstalk between viral replication and host differentiation programs. In this review, we discuss the regulation of the HPV lifecycle controlled by the differentiation program of the host cells. Frontiers Research Foundation 2012-04-24 /pmc/articles/PMC3334820/ /pubmed/22536200 http://dx.doi.org/10.3389/fmicb.2012.00152 Text en Copyright © 2012 Kajitani, Satsuka, Kawate and Sakai. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Microbiology Kajitani, Naoko Satsuka, Ayano Kawate, Akifumi Sakai, Hiroyuki Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation |
title | Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation |
title_full | Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation |
title_fullStr | Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation |
title_full_unstemmed | Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation |
title_short | Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation |
title_sort | productive lifecycle of human papillomaviruses that depends upon squamous epithelial differentiation |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334820/ https://www.ncbi.nlm.nih.gov/pubmed/22536200 http://dx.doi.org/10.3389/fmicb.2012.00152 |
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