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Two-dimensional infrared spectroscopy reveals the complex behavior of an amyloid fibril inhibitor

While amyloid formation has been implicated in the pathology of over twenty human diseases, the rational design of amyloid inhibitors is hampered by a lack of structural information about amyloid-inhibitor complexes. We use isotope labeling and two-dimensional infrared spectroscopy to obtain a resid...

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Detalles Bibliográficos
Autores principales:	Middleton, Chris T., Marek, Peter, Cao, Ping, Chiu, Chi-cheng, Singh, Sadanand, Woys, Ann Marie, de Pablo, Juan J., Raleigh, Daniel P., Zanni, Martin T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334878/ https://www.ncbi.nlm.nih.gov/pubmed/22522254 http://dx.doi.org/10.1038/nchem.1293

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