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How does viral DNA find the nucleus of an infected cell?
If all locations of a living cell would have the same chemical potential, most viral infections of a cell should be abortive, even after the a penetration of the cell wall by the viral DNA-polymer or viral RNA-polymer occurred. This is obviously not the case. Therefore, there must be a mechanism whi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
German Medical Science GMS Publishing House
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334944/ https://www.ncbi.nlm.nih.gov/pubmed/22558035 http://dx.doi.org/10.3205/dgkh000185 |
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author | Widulle, Herbert |
author_facet | Widulle, Herbert |
author_sort | Widulle, Herbert |
collection | PubMed |
description | If all locations of a living cell would have the same chemical potential, most viral infections of a cell should be abortive, even after the a penetration of the cell wall by the viral DNA-polymer or viral RNA-polymer occurred. This is obviously not the case. Therefore, there must be a mechanism which transports a viral DNA-polymer from the cell wall to the nucleus and not to any other location. A possible mechanism is proposed which is in accordance with biophysical chemistry. The presented description of the mechanism uses non equilibrium thermodynamics to find a simple solution for the problem. |
format | Online Article Text |
id | pubmed-3334944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | German Medical Science GMS Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-33349442012-05-03 How does viral DNA find the nucleus of an infected cell? Widulle, Herbert GMS Krankenhhyg Interdiszip Article If all locations of a living cell would have the same chemical potential, most viral infections of a cell should be abortive, even after the a penetration of the cell wall by the viral DNA-polymer or viral RNA-polymer occurred. This is obviously not the case. Therefore, there must be a mechanism which transports a viral DNA-polymer from the cell wall to the nucleus and not to any other location. A possible mechanism is proposed which is in accordance with biophysical chemistry. The presented description of the mechanism uses non equilibrium thermodynamics to find a simple solution for the problem. German Medical Science GMS Publishing House 2012-04-04 /pmc/articles/PMC3334944/ /pubmed/22558035 http://dx.doi.org/10.3205/dgkh000185 Text en Copyright © 2012 Widulle http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Article Widulle, Herbert How does viral DNA find the nucleus of an infected cell? |
title | How does viral DNA find the nucleus of an infected cell? |
title_full | How does viral DNA find the nucleus of an infected cell? |
title_fullStr | How does viral DNA find the nucleus of an infected cell? |
title_full_unstemmed | How does viral DNA find the nucleus of an infected cell? |
title_short | How does viral DNA find the nucleus of an infected cell? |
title_sort | how does viral dna find the nucleus of an infected cell? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334944/ https://www.ncbi.nlm.nih.gov/pubmed/22558035 http://dx.doi.org/10.3205/dgkh000185 |
work_keys_str_mv | AT widulleherbert howdoesviraldnafindthenucleusofaninfectedcell |