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Enhanced Brain Disposition and Effects of Δ(9)-Tetrahydrocannabinol in P-Glycoprotein and Breast Cancer Resistance Protein Knockout Mice

The ABC transporters P-glycoprotein (P-gp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) regulate the CNS disposition of many drugs. The main psychoactive constituent of cannabis Δ(9)-tetrahydrocannabinol (THC) has affinity for P-gp and Bcrp, however it is unknown whether these transport...

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Detalles Bibliográficos
Autores principales:	Spiro, Adena S., Wong, Alexander, Boucher, Aurélie A., Arnold, Jonathon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335007/ https://www.ncbi.nlm.nih.gov/pubmed/22536451 http://dx.doi.org/10.1371/journal.pone.0035937

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