Routine Multiplex Mutational Profiling of Melanomas Enables Enrollment in Genotype-Driven Therapeutic Trials

PURPOSE: Knowledge of tumor mutation status is becoming increasingly important for the treatment of cancer, as mutation-specific inhibitors are being developed for clinical use that target only sub-populations of patients with particular tumor genotypes. Melanoma provides a recent example of this pa...

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Detalles Bibliográficos
Autores principales: Lovly, Christine M., Dahlman, Kimberly Brown, Fohn, Laurel E., Su, Zengliu, Dias-Santagata, Dora, Hicks, Donna J., Hucks, Donald, Berry, Elizabeth, Terry, Charles, Duke, MarKeesa, Su, Yingjun, Sobolik-Delmaire, Tammy, Richmond, Ann, Kelley, Mark C., Vnencak-Jones, Cindy L., Iafrate, A. John, Sosman, Jeffrey, Pao, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335021/
https://www.ncbi.nlm.nih.gov/pubmed/22536370
http://dx.doi.org/10.1371/journal.pone.0035309

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