A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with a polygenic mode of inheritance. This study examined the hypothesis that runs of homozygosity (ROHs) play a recessive-acting role in the underlying RA genetic mechanism and identified RA-associated ROHs. Ours is the first genome-wide...

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Detalles Bibliográficos
Autores principales: Yang, Hsin-Chou, Chang, Lun-Ching, Liang, Yu-Jen, Lin, Chien-Hsing, Wang, Pei-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335047/
https://www.ncbi.nlm.nih.gov/pubmed/22536334
http://dx.doi.org/10.1371/journal.pone.0034840

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