Targeted Overexpression of Osteoactivin in Cells of Osteoclastic Lineage Promotes Osteoclastic Resorption and Bone Loss in Mice

This study sought to test whether targeted overexpression of osteoactivin (OA) in cells of osteoclastic lineage, using the tartrate-resistant acid phosphase (TRAP) exon 1B/C promoter to drive OA expression, would increase bone resorption and bone loss in vivo. OA transgenic osteoclasts showed ∼2-fol...

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Detalles Bibliográficos
Autores principales: Sheng, Matilda H.-C., Wergedal, Jon E., Mohan, Subburaman, Amoui, Mehran, Baylink, David J., Lau, K.-H. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335057/
https://www.ncbi.nlm.nih.gov/pubmed/22536365
http://dx.doi.org/10.1371/journal.pone.0035280

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