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Outside-In Signalling Generated by a Constitutively Activated Integrin α(IIb)β(3) Impairs Proplatelet Formation in Human Megakaryocytes

BACKGROUND: The interaction of megakaryocytes with matrix proteins of the osteoblastic and vascular niche is essential for megakaryocyte maturation and proplatelet formation. Fibrinogen is present in the vascular niche and the fibrinogen receptor α(IIb)β(3) is abundantly expressed on megakaryocytes,...

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Detalles Bibliográficos
Autores principales:	Bury, Loredana, Malara, Alessandro, Gresele, Paolo, Balduini, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335122/ https://www.ncbi.nlm.nih.gov/pubmed/22539947 http://dx.doi.org/10.1371/journal.pone.0034449

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