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ANG-1 TIE-2 and BMPR Signalling Defects Are Not Seen in the Nitrofen Model of Pulmonary Hypertension and Congenital Diaphragmatic Hernia

BACKGROUND: Pulmonary hypertension (PH) is a lethal disease that is associated with characteristic histological abnormalities of the lung vasculature and defects of angiopoetin-1 (ANG-1), TIE-2 and bone morphogenetic protein receptor (BMPR)-related signalling. We hypothesized that if these signallin...

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Detalles Bibliográficos
Autores principales: Corbett, Harriet Jane, Connell, Marilyn Gwen, Fernig, David Garth, Losty, Paul Damion, Jesudason, Edwin Chitran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335125/
https://www.ncbi.nlm.nih.gov/pubmed/22539968
http://dx.doi.org/10.1371/journal.pone.0035364