Role of NKT Cells in the Pathogenesis of NAFLD

Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression. NKT cells may have a protective role...

Descripción completa

Detalles Bibliográficos
Autores principales: Tajiri, Kazuto, Shimizu, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335183/
https://www.ncbi.nlm.nih.gov/pubmed/22577564
http://dx.doi.org/10.1155/2012/850836
_version_ 1782230762242703360
author Tajiri, Kazuto
Shimizu, Yukihiro
author_facet Tajiri, Kazuto
Shimizu, Yukihiro
author_sort Tajiri, Kazuto
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression. NKT cells may have a protective role at the early stage with simple steatosis through modification of insulin resistance, whereas they act as a progression factor at the advanced stage with fibrosis. Those processes are thought to depend on interaction between NKT cells and CD1d molecule in the liver.
format Online
Article
Text
id pubmed-3335183
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33351832012-05-10 Role of NKT Cells in the Pathogenesis of NAFLD Tajiri, Kazuto Shimizu, Yukihiro Int J Hepatol Review Article Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression. NKT cells may have a protective role at the early stage with simple steatosis through modification of insulin resistance, whereas they act as a progression factor at the advanced stage with fibrosis. Those processes are thought to depend on interaction between NKT cells and CD1d molecule in the liver. Hindawi Publishing Corporation 2012 2012-04-05 /pmc/articles/PMC3335183/ /pubmed/22577564 http://dx.doi.org/10.1155/2012/850836 Text en Copyright © 2012 K. Tajiri and Y. Shimizu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tajiri, Kazuto
Shimizu, Yukihiro
Role of NKT Cells in the Pathogenesis of NAFLD
title Role of NKT Cells in the Pathogenesis of NAFLD
title_full Role of NKT Cells in the Pathogenesis of NAFLD
title_fullStr Role of NKT Cells in the Pathogenesis of NAFLD
title_full_unstemmed Role of NKT Cells in the Pathogenesis of NAFLD
title_short Role of NKT Cells in the Pathogenesis of NAFLD
title_sort role of nkt cells in the pathogenesis of nafld
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335183/
https://www.ncbi.nlm.nih.gov/pubmed/22577564
http://dx.doi.org/10.1155/2012/850836
work_keys_str_mv AT tajirikazuto roleofnktcellsinthepathogenesisofnafld
AT shimizuyukihiro roleofnktcellsinthepathogenesisofnafld

Ejemplares similares