Bioanalytical Method Development and Validation of Memantine in Human Plasma by High Performance Liquid Chromatography with Tandem Mass Spectrometry: Application to Bioequivalence Study

A simple, sensitive, and rapid HPLC-MS/MS method was developed and validated for quantitative estimation of memantine in human plasma. Chromatography was performed on Zorbax SB-C(18) (4.6 × 75 mm, 3.5 μm) column. Memantine (ME) and internal standard Memantine-d6(MED6) were extracted by using liquid-...

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Detalles Bibliográficos
Autores principales: Konda, Ravi Kumar, Challa, B. R., Chandu, Babu Rao, Chandrasekhar, Kothapalli B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335321/
https://www.ncbi.nlm.nih.gov/pubmed/22567548
http://dx.doi.org/10.1155/2012/101249

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