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Molecular Aspects of Breast Cancer Metastasis to the Brain
Our knowledge of the biology underlying the development of brain metastases (BM) from breast cancer has improved over the last decade due to large clinical epidemiological studies, animal models of metastasis, and the use of high-resolution gene expression profiling technologies. However, there are...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335473/ https://www.ncbi.nlm.nih.gov/pubmed/22567347 http://dx.doi.org/10.4061/2011/219189 |
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author | Saunus, Jodi M. Momeny, Majid Simpson, Peter T. Lakhani, Sunil R. Da Silva, Leonard |
author_facet | Saunus, Jodi M. Momeny, Majid Simpson, Peter T. Lakhani, Sunil R. Da Silva, Leonard |
author_sort | Saunus, Jodi M. |
collection | PubMed |
description | Our knowledge of the biology underlying the development of brain metastases (BM) from breast cancer has improved over the last decade due to large clinical epidemiological studies, animal models of metastasis, and the use of high-resolution gene expression profiling technologies. However, there are still major gaps in our understanding of the mechanisms utilized by breast cancer cells to colonize the brain microenvironment, thus our arsenal of therapies remains relatively nonspecific, and the prognosis for breast cancer patients with BM remains poor. Additional insights into these mechanisms are necessary to facilitate the development of new preventive and curative therapeutic regimens to block this fatal disease. This paper aims to provide a general overview for the readers of what has been achieved in this field of research and its translation into clinical practice to date and to highlight exciting new areas of research that promise to inform the development of new targeted therapies for BM. |
format | Online Article Text |
id | pubmed-3335473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-33354732012-05-07 Molecular Aspects of Breast Cancer Metastasis to the Brain Saunus, Jodi M. Momeny, Majid Simpson, Peter T. Lakhani, Sunil R. Da Silva, Leonard Genet Res Int Review Article Our knowledge of the biology underlying the development of brain metastases (BM) from breast cancer has improved over the last decade due to large clinical epidemiological studies, animal models of metastasis, and the use of high-resolution gene expression profiling technologies. However, there are still major gaps in our understanding of the mechanisms utilized by breast cancer cells to colonize the brain microenvironment, thus our arsenal of therapies remains relatively nonspecific, and the prognosis for breast cancer patients with BM remains poor. Additional insights into these mechanisms are necessary to facilitate the development of new preventive and curative therapeutic regimens to block this fatal disease. This paper aims to provide a general overview for the readers of what has been achieved in this field of research and its translation into clinical practice to date and to highlight exciting new areas of research that promise to inform the development of new targeted therapies for BM. SAGE-Hindawi Access to Research 2011 2011-11-29 /pmc/articles/PMC3335473/ /pubmed/22567347 http://dx.doi.org/10.4061/2011/219189 Text en Copyright © 2011 Jodi M. Saunus et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Saunus, Jodi M. Momeny, Majid Simpson, Peter T. Lakhani, Sunil R. Da Silva, Leonard Molecular Aspects of Breast Cancer Metastasis to the Brain |
title | Molecular Aspects of Breast Cancer Metastasis to the Brain |
title_full | Molecular Aspects of Breast Cancer Metastasis to the Brain |
title_fullStr | Molecular Aspects of Breast Cancer Metastasis to the Brain |
title_full_unstemmed | Molecular Aspects of Breast Cancer Metastasis to the Brain |
title_short | Molecular Aspects of Breast Cancer Metastasis to the Brain |
title_sort | molecular aspects of breast cancer metastasis to the brain |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335473/ https://www.ncbi.nlm.nih.gov/pubmed/22567347 http://dx.doi.org/10.4061/2011/219189 |
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