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The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis
Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium tuberculosis infection. They cannot differentiate between latent and active infections. The cutoff suggested by the manufacturer is 0.35 IU/mL for latent tuberculosis. As IGRA tests were...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335531/ https://www.ncbi.nlm.nih.gov/pubmed/22567275 http://dx.doi.org/10.1155/2012/768723 |
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author | Vesenbeckh, Silvan M. Schönfeld, Nicolas Mauch, Harald Bergmann, Thorsten Wagner, Sonja Bauer, Torsten T. Rüssmann, Holger |
author_facet | Vesenbeckh, Silvan M. Schönfeld, Nicolas Mauch, Harald Bergmann, Thorsten Wagner, Sonja Bauer, Torsten T. Rüssmann, Holger |
author_sort | Vesenbeckh, Silvan M. |
collection | PubMed |
description | Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium tuberculosis infection. They cannot differentiate between latent and active infections. The cutoff suggested by the manufacturer is 0.35 IU/mL for latent tuberculosis. As IGRA tests were recently approved for the differential diagnosis of active tuberculosis, we assessed the diagnostic accuracy of the latest generation IGRA for detection of active tuberculosis in a low-incidence area in Germany. Our consecutive case series includes 61 HIV negative, Mycobacterium tuberculosis culture positive patients, as well as 234 control patients. The retrospective analysis was performed over a period of two years. In 11/61 patients with active tuberculosis (18.0%) the test result was <0.35 IU/mL, resulting in a sensitivity of 0.82. We recommend establishing a new cut-off value for the differential diagnosis of active tuberculosis assessed by prospective clinical studies and in various regions with high and low prevalence of tuberculosis. |
format | Online Article Text |
id | pubmed-3335531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33355312012-05-07 The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis Vesenbeckh, Silvan M. Schönfeld, Nicolas Mauch, Harald Bergmann, Thorsten Wagner, Sonja Bauer, Torsten T. Rüssmann, Holger Tuberc Res Treat Clinical Study Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium tuberculosis infection. They cannot differentiate between latent and active infections. The cutoff suggested by the manufacturer is 0.35 IU/mL for latent tuberculosis. As IGRA tests were recently approved for the differential diagnosis of active tuberculosis, we assessed the diagnostic accuracy of the latest generation IGRA for detection of active tuberculosis in a low-incidence area in Germany. Our consecutive case series includes 61 HIV negative, Mycobacterium tuberculosis culture positive patients, as well as 234 control patients. The retrospective analysis was performed over a period of two years. In 11/61 patients with active tuberculosis (18.0%) the test result was <0.35 IU/mL, resulting in a sensitivity of 0.82. We recommend establishing a new cut-off value for the differential diagnosis of active tuberculosis assessed by prospective clinical studies and in various regions with high and low prevalence of tuberculosis. Hindawi Publishing Corporation 2012 2012-01-22 /pmc/articles/PMC3335531/ /pubmed/22567275 http://dx.doi.org/10.1155/2012/768723 Text en Copyright © 2012 Silvan M. Vesenbeckh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Vesenbeckh, Silvan M. Schönfeld, Nicolas Mauch, Harald Bergmann, Thorsten Wagner, Sonja Bauer, Torsten T. Rüssmann, Holger The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis |
title | The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis |
title_full | The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis |
title_fullStr | The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis |
title_full_unstemmed | The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis |
title_short | The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis |
title_sort | use of interferon gamma release assays in the diagnosis of active tuberculosis |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335531/ https://www.ncbi.nlm.nih.gov/pubmed/22567275 http://dx.doi.org/10.1155/2012/768723 |
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