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BCG Vaccination in HIV-Infected Children
Despite the use of Bacillus Calmette-Guérin (BCG) vaccination for many years, infants and young children exposed to adults with infectious forms of tuberculosis (TB) are at high risk of developing complicated TB disease. This risk is much higher among HIV-infected children, and data on BCG protectiv...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335547/ https://www.ncbi.nlm.nih.gov/pubmed/22567268 http://dx.doi.org/10.1155/2011/712736 |
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author | Nuttall, James J. C. Eley, Brian S. |
author_facet | Nuttall, James J. C. Eley, Brian S. |
author_sort | Nuttall, James J. C. |
collection | PubMed |
description | Despite the use of Bacillus Calmette-Guérin (BCG) vaccination for many years, infants and young children exposed to adults with infectious forms of tuberculosis (TB) are at high risk of developing complicated TB disease. This risk is much higher among HIV-infected children, and data on BCG protective efficacy in HIV-infected children is lacking. Recent research on BCG safety in HIV-infected infants has resulted in policy shifts, but implementation is challenging. New approaches to preventing TB among infants and children, particularly HIV-infected infants, are needed. This paper briefly reviews BCG safety and efficacy considerations in HIV-infected infants and discusses other approaches to preventing TB, including new TB vaccines and vaccination strategies. |
format | Online Article Text |
id | pubmed-3335547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33355472012-05-07 BCG Vaccination in HIV-Infected Children Nuttall, James J. C. Eley, Brian S. Tuberc Res Treat Review Article Despite the use of Bacillus Calmette-Guérin (BCG) vaccination for many years, infants and young children exposed to adults with infectious forms of tuberculosis (TB) are at high risk of developing complicated TB disease. This risk is much higher among HIV-infected children, and data on BCG protective efficacy in HIV-infected children is lacking. Recent research on BCG safety in HIV-infected infants has resulted in policy shifts, but implementation is challenging. New approaches to preventing TB among infants and children, particularly HIV-infected infants, are needed. This paper briefly reviews BCG safety and efficacy considerations in HIV-infected infants and discusses other approaches to preventing TB, including new TB vaccines and vaccination strategies. Hindawi Publishing Corporation 2011 2011-04-10 /pmc/articles/PMC3335547/ /pubmed/22567268 http://dx.doi.org/10.1155/2011/712736 Text en Copyright © 2011 J. J. C. Nuttall and B. S. Eley. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nuttall, James J. C. Eley, Brian S. BCG Vaccination in HIV-Infected Children |
title | BCG Vaccination in HIV-Infected Children |
title_full | BCG Vaccination in HIV-Infected Children |
title_fullStr | BCG Vaccination in HIV-Infected Children |
title_full_unstemmed | BCG Vaccination in HIV-Infected Children |
title_short | BCG Vaccination in HIV-Infected Children |
title_sort | bcg vaccination in hiv-infected children |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335547/ https://www.ncbi.nlm.nih.gov/pubmed/22567268 http://dx.doi.org/10.1155/2011/712736 |
work_keys_str_mv | AT nuttalljamesjc bcgvaccinationinhivinfectedchildren AT eleybrians bcgvaccinationinhivinfectedchildren |