Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription

Dosage compensation balances gene expression levels between the sex chromosomes and autosomes and sex-chromosome-linked gene expression levels between the sexes. Different dosage compensation strategies evolved in different lineages, but all involve changes in chromatin. This paper discusses our cur...

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Detalles Bibliográficos
Autores principales: Wells, Michael B., Csankovszki, Györgyi, Custer, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335593/
https://www.ncbi.nlm.nih.gov/pubmed/22567401
http://dx.doi.org/10.1155/2012/795069
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author Wells, Michael B.
Csankovszki, Györgyi
Custer, Laura M.
author_facet Wells, Michael B.
Csankovszki, Györgyi
Custer, Laura M.
author_sort Wells, Michael B.
collection PubMed
description Dosage compensation balances gene expression levels between the sex chromosomes and autosomes and sex-chromosome-linked gene expression levels between the sexes. Different dosage compensation strategies evolved in different lineages, but all involve changes in chromatin. This paper discusses our current understanding of how modifications of the histone H4 tail, particularly changes in levels of H4 lysine 16 acetylation and H4 lysine 20 methylation, can be used in different contexts to either modulate gene expression levels twofold or to completely inhibit transcription.
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spelling pubmed-33355932012-05-07 Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription Wells, Michael B. Csankovszki, Györgyi Custer, Laura M. Genet Res Int Review Article Dosage compensation balances gene expression levels between the sex chromosomes and autosomes and sex-chromosome-linked gene expression levels between the sexes. Different dosage compensation strategies evolved in different lineages, but all involve changes in chromatin. This paper discusses our current understanding of how modifications of the histone H4 tail, particularly changes in levels of H4 lysine 16 acetylation and H4 lysine 20 methylation, can be used in different contexts to either modulate gene expression levels twofold or to completely inhibit transcription. Hindawi Publishing Corporation 2012 2011-10-19 /pmc/articles/PMC3335593/ /pubmed/22567401 http://dx.doi.org/10.1155/2012/795069 Text en Copyright © 2012 Michael B. Wells et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wells, Michael B.
Csankovszki, Györgyi
Custer, Laura M.
Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription
title Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription
title_full Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription
title_fullStr Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription
title_full_unstemmed Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription
title_short Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription
title_sort finding a balance: how diverse dosage compensation strategies modify histone h4 to regulate transcription
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335593/
https://www.ncbi.nlm.nih.gov/pubmed/22567401
http://dx.doi.org/10.1155/2012/795069
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