Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis

Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazon...

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Autores principales: Baquero, Eduard, Quiñones, Wiston, Ribon, Wellman, Caldas, Maria Leonor, Sarmiento, Ladys, Echeverri, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335653/
https://www.ncbi.nlm.nih.gov/pubmed/22567272
http://dx.doi.org/10.1155/2011/986409
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author Baquero, Eduard
Quiñones, Wiston
Ribon, Wellman
Caldas, Maria Leonor
Sarmiento, Ladys
Echeverri, Fernando
author_facet Baquero, Eduard
Quiñones, Wiston
Ribon, Wellman
Caldas, Maria Leonor
Sarmiento, Ladys
Echeverri, Fernando
author_sort Baquero, Eduard
collection PubMed
description Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.
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spelling pubmed-33356532012-05-07 Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis Baquero, Eduard Quiñones, Wiston Ribon, Wellman Caldas, Maria Leonor Sarmiento, Ladys Echeverri, Fernando Tuberc Res Treat Research Article Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology. Hindawi Publishing Corporation 2011 2011-04-11 /pmc/articles/PMC3335653/ /pubmed/22567272 http://dx.doi.org/10.1155/2011/986409 Text en Copyright © 2011 Eduard Baquero et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Baquero, Eduard
Quiñones, Wiston
Ribon, Wellman
Caldas, Maria Leonor
Sarmiento, Ladys
Echeverri, Fernando
Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_full Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_fullStr Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_full_unstemmed Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_short Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_sort effect of an oxadiazoline and a lignan on mycolic acid biosynthesis and ultrastructural changes of mycobacterium tuberculosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335653/
https://www.ncbi.nlm.nih.gov/pubmed/22567272
http://dx.doi.org/10.1155/2011/986409
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