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Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First?
Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35–47S) can be achieved by up to 150 RNA polymerase I (Pol I) enzymes simultaneously transcribing each rRNA gene. In this paper, we present recent advances made in understand...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335655/ https://www.ncbi.nlm.nih.gov/pubmed/22567380 http://dx.doi.org/10.1155/2012/276948 |
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author | Albert, Benjamin Perez-Fernandez, Jorge Léger-Silvestre, Isabelle Gadal, Olivier |
author_facet | Albert, Benjamin Perez-Fernandez, Jorge Léger-Silvestre, Isabelle Gadal, Olivier |
author_sort | Albert, Benjamin |
collection | PubMed |
description | Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35–47S) can be achieved by up to 150 RNA polymerase I (Pol I) enzymes simultaneously transcribing each rRNA gene. In this paper, we present recent advances made in understanding the regulatory mechanisms that control elongation. Built-in Pol I elongation factors, such as Rpa34/Rpa49 in budding yeast and PAF53/CAST in humans, are instrumental to the extremely high rate of rRNA production per gene. rRNA elongation mechanisms are intrinsically linked to chromatin structure and to the higher-order organization of the rRNA genes (rDNA). Factors such as Hmo1 in yeast and UBF1 in humans are key players in rDNA chromatin structure in vivo. Finally, elongation factors known to regulate messengers RNA production by RNA polymerase II are also involved in rRNA production and work cooperatively with Rpa49 in vivo. |
format | Online Article Text |
id | pubmed-3335655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33356552012-05-07 Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First? Albert, Benjamin Perez-Fernandez, Jorge Léger-Silvestre, Isabelle Gadal, Olivier Genet Res Int Review Article Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35–47S) can be achieved by up to 150 RNA polymerase I (Pol I) enzymes simultaneously transcribing each rRNA gene. In this paper, we present recent advances made in understanding the regulatory mechanisms that control elongation. Built-in Pol I elongation factors, such as Rpa34/Rpa49 in budding yeast and PAF53/CAST in humans, are instrumental to the extremely high rate of rRNA production per gene. rRNA elongation mechanisms are intrinsically linked to chromatin structure and to the higher-order organization of the rRNA genes (rDNA). Factors such as Hmo1 in yeast and UBF1 in humans are key players in rDNA chromatin structure in vivo. Finally, elongation factors known to regulate messengers RNA production by RNA polymerase II are also involved in rRNA production and work cooperatively with Rpa49 in vivo. Hindawi Publishing Corporation 2012 2012-01-12 /pmc/articles/PMC3335655/ /pubmed/22567380 http://dx.doi.org/10.1155/2012/276948 Text en Copyright © 2012 Benjamin Albert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Albert, Benjamin Perez-Fernandez, Jorge Léger-Silvestre, Isabelle Gadal, Olivier Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First? |
title | Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First? |
title_full | Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First? |
title_fullStr | Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First? |
title_full_unstemmed | Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First? |
title_short | Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First? |
title_sort | regulation of ribosomal rna production by rna polymerase i: does elongation come first? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335655/ https://www.ncbi.nlm.nih.gov/pubmed/22567380 http://dx.doi.org/10.1155/2012/276948 |
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