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Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis

Yersiniosis is a food-borne illness that has become more prevalent in recent years due to human transmission via the fecal-oral route and prevalence in farm animals. Yersiniosis is primarily caused by Yersinia enterocolitica and less frequently by Yersinia pseudotuberculosis. Infection is usually ch...

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Autores principales: Galindo, Cristi L., Rosenzweig, Jason A., Kirtley, Michelle L., Chopra, Ashok K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335670/
https://www.ncbi.nlm.nih.gov/pubmed/22567322
http://dx.doi.org/10.4061/2011/182051
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author Galindo, Cristi L.
Rosenzweig, Jason A.
Kirtley, Michelle L.
Chopra, Ashok K.
author_facet Galindo, Cristi L.
Rosenzweig, Jason A.
Kirtley, Michelle L.
Chopra, Ashok K.
author_sort Galindo, Cristi L.
collection PubMed
description Yersiniosis is a food-borne illness that has become more prevalent in recent years due to human transmission via the fecal-oral route and prevalence in farm animals. Yersiniosis is primarily caused by Yersinia enterocolitica and less frequently by Yersinia pseudotuberculosis. Infection is usually characterized by a self-limiting acute infection beginning in the intestine and spreading to the mesenteric lymph nodes. However, more serious infections and chronic conditions can also occur, particularly in immunocompromised individuals. Y. enterocolitica and Y. pseudotuberculosis are both heterogeneous organisms that vary considerably in their degrees of pathogenicity, although some generalizations can be ascribed to pathogenic variants. Adhesion molecules and a type III secretion system are critical for the establishment and progression of infection. Additionally, host innate and adaptive immune responses are both required for yersiniae clearance. Despite the ubiquity of enteric Yersinia species and their association as important causes of food poisoning world-wide, few national enteric pathogen surveillance programs include the yersiniae as notifiable pathogens. Moreover, no standard exists whereby identification and reporting systems can be effectively compared and global trends developed. This review discusses yersinial virulence factors, mechanisms of infection, and host responses in addition to the current state of surveillance, detection, and prevention of yersiniosis.
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spelling pubmed-33356702012-05-07 Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis Galindo, Cristi L. Rosenzweig, Jason A. Kirtley, Michelle L. Chopra, Ashok K. J Pathog Review Article Yersiniosis is a food-borne illness that has become more prevalent in recent years due to human transmission via the fecal-oral route and prevalence in farm animals. Yersiniosis is primarily caused by Yersinia enterocolitica and less frequently by Yersinia pseudotuberculosis. Infection is usually characterized by a self-limiting acute infection beginning in the intestine and spreading to the mesenteric lymph nodes. However, more serious infections and chronic conditions can also occur, particularly in immunocompromised individuals. Y. enterocolitica and Y. pseudotuberculosis are both heterogeneous organisms that vary considerably in their degrees of pathogenicity, although some generalizations can be ascribed to pathogenic variants. Adhesion molecules and a type III secretion system are critical for the establishment and progression of infection. Additionally, host innate and adaptive immune responses are both required for yersiniae clearance. Despite the ubiquity of enteric Yersinia species and their association as important causes of food poisoning world-wide, few national enteric pathogen surveillance programs include the yersiniae as notifiable pathogens. Moreover, no standard exists whereby identification and reporting systems can be effectively compared and global trends developed. This review discusses yersinial virulence factors, mechanisms of infection, and host responses in addition to the current state of surveillance, detection, and prevention of yersiniosis. SAGE-Hindawi Access to Research 2011 2011-09-12 /pmc/articles/PMC3335670/ /pubmed/22567322 http://dx.doi.org/10.4061/2011/182051 Text en Copyright © 2011 Cristi L. Galindo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Galindo, Cristi L.
Rosenzweig, Jason A.
Kirtley, Michelle L.
Chopra, Ashok K.
Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis
title Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis
title_full Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis
title_fullStr Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis
title_full_unstemmed Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis
title_short Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis
title_sort pathogenesis of y. enterocolitica and y. pseudotuberculosis in human yersiniosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335670/
https://www.ncbi.nlm.nih.gov/pubmed/22567322
http://dx.doi.org/10.4061/2011/182051
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