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Elongating under Stress
In response to extracellular stimuli, mitogen-activated protein kinases (MAPKs) modulate gene expression to maximize cell survival. Exposure of yeast to high osmolarity results in activation of the p38-related MAPK Hog1, which plays a key role in reprogramming the gene expression pattern required fo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335722/ https://www.ncbi.nlm.nih.gov/pubmed/22567351 http://dx.doi.org/10.4061/2011/326286 |
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author | de Nadal, Eulàlia Posas, Francesc |
author_facet | de Nadal, Eulàlia Posas, Francesc |
author_sort | de Nadal, Eulàlia |
collection | PubMed |
description | In response to extracellular stimuli, mitogen-activated protein kinases (MAPKs) modulate gene expression to maximize cell survival. Exposure of yeast to high osmolarity results in activation of the p38-related MAPK Hog1, which plays a key role in reprogramming the gene expression pattern required for cell survival upon osmostress. Hog1 not only regulates initiation but also modulates other steps of the transcription process. Recent work indicates that other yeast signalling MAPKs such as Mpk1 modulate transcriptional elongation in response to cell wall stress. Similarly, mammalian MAPKs have also been found associated to coding regions of stress-responsive genes. In this paper, significant progress in MAPK-regulated events that occur during the transcriptional elongation step is summarized, and future directions are discussed. We expect that the principles learned from these studies will provide a new understanding of the regulation of gene expression by signalling kinases. |
format | Online Article Text |
id | pubmed-3335722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-33357222012-05-07 Elongating under Stress de Nadal, Eulàlia Posas, Francesc Genet Res Int Review Article In response to extracellular stimuli, mitogen-activated protein kinases (MAPKs) modulate gene expression to maximize cell survival. Exposure of yeast to high osmolarity results in activation of the p38-related MAPK Hog1, which plays a key role in reprogramming the gene expression pattern required for cell survival upon osmostress. Hog1 not only regulates initiation but also modulates other steps of the transcription process. Recent work indicates that other yeast signalling MAPKs such as Mpk1 modulate transcriptional elongation in response to cell wall stress. Similarly, mammalian MAPKs have also been found associated to coding regions of stress-responsive genes. In this paper, significant progress in MAPK-regulated events that occur during the transcriptional elongation step is summarized, and future directions are discussed. We expect that the principles learned from these studies will provide a new understanding of the regulation of gene expression by signalling kinases. SAGE-Hindawi Access to Research 2011 2011-09-07 /pmc/articles/PMC3335722/ /pubmed/22567351 http://dx.doi.org/10.4061/2011/326286 Text en Copyright © 2011 E. de Nadal and F. Posas. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article de Nadal, Eulàlia Posas, Francesc Elongating under Stress |
title | Elongating under Stress |
title_full | Elongating under Stress |
title_fullStr | Elongating under Stress |
title_full_unstemmed | Elongating under Stress |
title_short | Elongating under Stress |
title_sort | elongating under stress |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335722/ https://www.ncbi.nlm.nih.gov/pubmed/22567351 http://dx.doi.org/10.4061/2011/326286 |
work_keys_str_mv | AT denadaleulalia elongatingunderstress AT posasfrancesc elongatingunderstress |