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Knockdown of Amyloid Precursor Protein in Zebrafish Causes Defects in Motor Axon Outgrowth
Amyloid precursor protein (APP) plays a pivotal role in Alzheimer’s disease (AD) pathogenesis, but its normal physiological functions are less clear. Combined deletion of the APP and APP-like protein 2 (APLP2) genes in mice results in post-natal lethality, suggesting that APP performs an essential,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335837/ https://www.ncbi.nlm.nih.gov/pubmed/22545081 http://dx.doi.org/10.1371/journal.pone.0034209 |