Inflammation-Driven Reprogramming of CD4(+)Foxp3(+) Regulatory T Cells into Pathogenic Th1/Th17 T Effectors Is Abrogated by mTOR Inhibition in vivo

While natural CD4(+)Foxp3(+) regulatory T (nT(REG)) cells have long been viewed as a stable and distinct lineage that is committed to suppressive functions in vivo, recent evidence supporting this notion remains highly controversial. We sought to determine whether Foxp3 expression and the nT(REG) ce...

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Detalles Bibliográficos
Autores principales: Yurchenko, Ekaterina, Shio, Marina T., Huang, Tony C., Da Silva Martins, Maria, Szyf, Moshe, Levings, Megan K., Olivier, Martin, Piccirillo, Ciriaco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335853/
https://www.ncbi.nlm.nih.gov/pubmed/22545118
http://dx.doi.org/10.1371/journal.pone.0035572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335853/
https://www.ncbi.nlm.nih.gov/pubmed/22545118
http://dx.doi.org/10.1371/journal.pone.0035572

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