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The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders
MicroRNAs (miRNAs) are small non-coding RNAs conserved throughout evolution whose perceived importance for brain development and maturation is increasingly being understood. Although a plethora of new discoveries have provided novel insights into miRNA-mediated molecular mechanisms that influence br...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336189/ https://www.ncbi.nlm.nih.gov/pubmed/22539927 http://dx.doi.org/10.3389/fpsyt.2012.00039 |
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author | Mellios, Nikolaos Sur, Mriganka |
author_facet | Mellios, Nikolaos Sur, Mriganka |
author_sort | Mellios, Nikolaos |
collection | PubMed |
description | MicroRNAs (miRNAs) are small non-coding RNAs conserved throughout evolution whose perceived importance for brain development and maturation is increasingly being understood. Although a plethora of new discoveries have provided novel insights into miRNA-mediated molecular mechanisms that influence brain plasticity, their relevance for neuropsychiatric diseases with known deficits in synaptic plasticity, such as schizophrenia and autism, has not been adequately explored. In this review we discuss the intersection between current and old knowledge on the role of miRNAs in brain plasticity and function with a focus in the potential involvement of brain expressed miRNAs in the pathophysiology of neuropsychiatric disorders. |
format | Online Article Text |
id | pubmed-3336189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33361892012-04-26 The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders Mellios, Nikolaos Sur, Mriganka Front Psychiatry Psychiatry MicroRNAs (miRNAs) are small non-coding RNAs conserved throughout evolution whose perceived importance for brain development and maturation is increasingly being understood. Although a plethora of new discoveries have provided novel insights into miRNA-mediated molecular mechanisms that influence brain plasticity, their relevance for neuropsychiatric diseases with known deficits in synaptic plasticity, such as schizophrenia and autism, has not been adequately explored. In this review we discuss the intersection between current and old knowledge on the role of miRNAs in brain plasticity and function with a focus in the potential involvement of brain expressed miRNAs in the pathophysiology of neuropsychiatric disorders. Frontiers Research Foundation 2012-04-25 /pmc/articles/PMC3336189/ /pubmed/22539927 http://dx.doi.org/10.3389/fpsyt.2012.00039 Text en Copyright © 2012 Mellios and Sur. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Psychiatry Mellios, Nikolaos Sur, Mriganka The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
title | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
title_full | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
title_fullStr | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
title_full_unstemmed | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
title_short | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
title_sort | emerging role of micrornas in schizophrenia and autism spectrum disorders |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336189/ https://www.ncbi.nlm.nih.gov/pubmed/22539927 http://dx.doi.org/10.3389/fpsyt.2012.00039 |
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