HEPATOTOXICITY OF EUGENOL

EUGENOL a widely used pharmaceutical agent proceeds toxicity on inhalation in rats. Two different doses 20 & 30 μg/100g body weight/ day of eugenol were given intramuscularly to male albino rats for 10 days and the liver function was assessed by measuring the specific enzyme activities, and tota...

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Detalles Bibliográficos
Autores principales: Soundran, Vijaya, Namagiri, Tara, Manonayaki, S., Vanithakumari, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 1994
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336525/
https://www.ncbi.nlm.nih.gov/pubmed/22556649
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author Soundran, Vijaya
Namagiri, Tara
Manonayaki, S.
Vanithakumari, G.
author_facet Soundran, Vijaya
Namagiri, Tara
Manonayaki, S.
Vanithakumari, G.
author_sort Soundran, Vijaya
collection PubMed
description EUGENOL a widely used pharmaceutical agent proceeds toxicity on inhalation in rats. Two different doses 20 & 30 μg/100g body weight/ day of eugenol were given intramuscularly to male albino rats for 10 days and the liver function was assessed by measuring the specific enzyme activities, and total and differential bilirubin concentration. There was an appreciable increase in total as well as differential bilirubin fractions and a dose dependent increase was noticed in the activities of alkaline phosphatase, transminases, lactate dehyrogenase with a decrease in the activity of glytamyl transferase activity, and suggesting eugenol to have a toxic effect on liver.
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spelling pubmed-33365252012-04-27 HEPATOTOXICITY OF EUGENOL Soundran, Vijaya Namagiri, Tara Manonayaki, S. Vanithakumari, G. Anc Sci Life Original Article EUGENOL a widely used pharmaceutical agent proceeds toxicity on inhalation in rats. Two different doses 20 & 30 μg/100g body weight/ day of eugenol were given intramuscularly to male albino rats for 10 days and the liver function was assessed by measuring the specific enzyme activities, and total and differential bilirubin concentration. There was an appreciable increase in total as well as differential bilirubin fractions and a dose dependent increase was noticed in the activities of alkaline phosphatase, transminases, lactate dehyrogenase with a decrease in the activity of glytamyl transferase activity, and suggesting eugenol to have a toxic effect on liver. Medknow Publications & Media Pvt Ltd 1994 /pmc/articles/PMC3336525/ /pubmed/22556649 Text en Copyright: © Ancient Science of Life http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Soundran, Vijaya
Namagiri, Tara
Manonayaki, S.
Vanithakumari, G.
HEPATOTOXICITY OF EUGENOL
title HEPATOTOXICITY OF EUGENOL
title_full HEPATOTOXICITY OF EUGENOL
title_fullStr HEPATOTOXICITY OF EUGENOL
title_full_unstemmed HEPATOTOXICITY OF EUGENOL
title_short HEPATOTOXICITY OF EUGENOL
title_sort hepatotoxicity of eugenol
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336525/
https://www.ncbi.nlm.nih.gov/pubmed/22556649
work_keys_str_mv AT soundranvijaya hepatotoxicityofeugenol
AT namagiritara hepatotoxicityofeugenol
AT manonayakis hepatotoxicityofeugenol
AT vanithakumarig hepatotoxicityofeugenol

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