IN VITRO STUDIES ON THYROGENIC EFFECT OF COMMIPHORA MUKUL (GUGGULU)

The results of this study has revealed a significant increase in I(131) uptake of cultivated thyroid gland in the media containing petroleum ether extract of Commiphora mukul. Besides, T(3) resin uptake, protein bound iodine as well as free thyroxine index in the media are also observed to be signif...

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Detalles Bibliográficos
Autores principales: Singh, A.K., Prasad, G.C, Tripathi, S.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 1982
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336708/
https://www.ncbi.nlm.nih.gov/pubmed/22556948
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author Singh, A.K.
Prasad, G.C
Tripathi, S.N.
author_facet Singh, A.K.
Prasad, G.C
Tripathi, S.N.
author_sort Singh, A.K.
collection PubMed
description The results of this study has revealed a significant increase in I(131) uptake of cultivated thyroid gland in the media containing petroleum ether extract of Commiphora mukul. Besides, T(3) resin uptake, protein bound iodine as well as free thyroxine index in the media are also observed to be significantly (P 0.001) increased. When explants are cultivated in the media containing melatonin, there is significant depression in thyroid I(131) uptake and media T(3) resin uptake, protein bound iodine as well as free thyroxine index. Further, the inhibitory action of melatonin has been antagonized when similar explants are cultivated in the media containing melatonin and P.E. extract of c. mukul together thus, C. mukul may be useful in the management of hypothyroidism and its associated disorders like, hypercholesterolemia, hyperlipidemia, atherosclerosis etc
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spelling pubmed-33367082012-04-27 IN VITRO STUDIES ON THYROGENIC EFFECT OF COMMIPHORA MUKUL (GUGGULU) Singh, A.K. Prasad, G.C Tripathi, S.N. Anc Sci Life Original Article The results of this study has revealed a significant increase in I(131) uptake of cultivated thyroid gland in the media containing petroleum ether extract of Commiphora mukul. Besides, T(3) resin uptake, protein bound iodine as well as free thyroxine index in the media are also observed to be significantly (P 0.001) increased. When explants are cultivated in the media containing melatonin, there is significant depression in thyroid I(131) uptake and media T(3) resin uptake, protein bound iodine as well as free thyroxine index. Further, the inhibitory action of melatonin has been antagonized when similar explants are cultivated in the media containing melatonin and P.E. extract of c. mukul together thus, C. mukul may be useful in the management of hypothyroidism and its associated disorders like, hypercholesterolemia, hyperlipidemia, atherosclerosis etc Medknow Publications & Media Pvt Ltd 1982 /pmc/articles/PMC3336708/ /pubmed/22556948 Text en Copyright: © Ancient Science of Life http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Singh, A.K.
Prasad, G.C
Tripathi, S.N.
IN VITRO STUDIES ON THYROGENIC EFFECT OF COMMIPHORA MUKUL (GUGGULU)
title IN VITRO STUDIES ON THYROGENIC EFFECT OF COMMIPHORA MUKUL (GUGGULU)
title_full IN VITRO STUDIES ON THYROGENIC EFFECT OF COMMIPHORA MUKUL (GUGGULU)
title_fullStr IN VITRO STUDIES ON THYROGENIC EFFECT OF COMMIPHORA MUKUL (GUGGULU)
title_full_unstemmed IN VITRO STUDIES ON THYROGENIC EFFECT OF COMMIPHORA MUKUL (GUGGULU)
title_short IN VITRO STUDIES ON THYROGENIC EFFECT OF COMMIPHORA MUKUL (GUGGULU)
title_sort in vitro studies on thyrogenic effect of commiphora mukul (guggulu)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336708/
https://www.ncbi.nlm.nih.gov/pubmed/22556948
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