STEROIDOGENIC EFFECT OF ALBIZZIA LEBBEK BENTH. IN GUINEA PIGS

Albizzia lebbek a renowned drug of Indian medicine for allergic diseases has been proved to be useful in bronchial asthma and histamine induced bronchospasm in guinea pigs. Mode of action of this drug is suggested through the adrenals as the rise in plasma cortisol is reported by the administration of A. Lebbek both in humanbeings and guinea pigs. The dose effect relationahip has been studied and 200 mg, (alcoholic extract of A. lebbek)/Kg. of body weight hag been found to be maximum effective dose in terms of stimulation of adrenals and rise in plasma cortisol. Vitamin C and Cholesterol content of adrenals has been estimated after the administration of the drug and a strictly significant fail wan noted as compared to control. Thus the steroidogenic action of A. lebbek is inferred and action is explained to bo like ACTH.