No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population

BACKGROUND: The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. AIMS: The aim of the present study was to investigate possible association between schizophrenia and Val...

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Detalles Bibliográficos
Autores principales: Lajin, Bassam, Alachkar, Amal, Hamzeh, Abdul Rezzak, Michati, Roula, Alhaj, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336908/
https://www.ncbi.nlm.nih.gov/pubmed/22540087
http://dx.doi.org/10.4297/najms.2011.3176
Descripción
Sumario:BACKGROUND: The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. AIMS: The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. METHODS AND MATERIALS: 71 unrelated schizophrenic subjects (45 men) and 102 unrelated healthy controls (62 men) were recruited to take part in this case- control study. The Val158Met of the COMT gene was genotyped for patients and controls, using a new optimized PCR-RFLP method. RESULTS: the results demonstrated that there is no statistically significant difference between the two groups. CONCLUSION: This study does not support that Val158Met has an influence on susceptibility for schizophrenia in this population.

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