No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population

BACKGROUND: The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. AIMS: The aim of the present study was to investigate possible association between schizophrenia and Val...

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Autores principales: Lajin, Bassam, Alachkar, Amal, Hamzeh, Abdul Rezzak, Michati, Roula, Alhaj, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336908/
https://www.ncbi.nlm.nih.gov/pubmed/22540087
http://dx.doi.org/10.4297/najms.2011.3176
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author Lajin, Bassam
Alachkar, Amal
Hamzeh, Abdul Rezzak
Michati, Roula
Alhaj, Hamid
author_facet Lajin, Bassam
Alachkar, Amal
Hamzeh, Abdul Rezzak
Michati, Roula
Alhaj, Hamid
author_sort Lajin, Bassam
collection PubMed
description BACKGROUND: The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. AIMS: The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. METHODS AND MATERIALS: 71 unrelated schizophrenic subjects (45 men) and 102 unrelated healthy controls (62 men) were recruited to take part in this case- control study. The Val158Met of the COMT gene was genotyped for patients and controls, using a new optimized PCR-RFLP method. RESULTS: the results demonstrated that there is no statistically significant difference between the two groups. CONCLUSION: This study does not support that Val158Met has an influence on susceptibility for schizophrenia in this population.
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spelling pubmed-33369082012-04-26 No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population Lajin, Bassam Alachkar, Amal Hamzeh, Abdul Rezzak Michati, Roula Alhaj, Hamid N Am J Med Sci Original Article BACKGROUND: The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. AIMS: The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. METHODS AND MATERIALS: 71 unrelated schizophrenic subjects (45 men) and 102 unrelated healthy controls (62 men) were recruited to take part in this case- control study. The Val158Met of the COMT gene was genotyped for patients and controls, using a new optimized PCR-RFLP method. RESULTS: the results demonstrated that there is no statistically significant difference between the two groups. CONCLUSION: This study does not support that Val158Met has an influence on susceptibility for schizophrenia in this population. Medknow Publications & Media Pvt Ltd 2011-04 /pmc/articles/PMC3336908/ /pubmed/22540087 http://dx.doi.org/10.4297/najms.2011.3176 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lajin, Bassam
Alachkar, Amal
Hamzeh, Abdul Rezzak
Michati, Roula
Alhaj, Hamid
No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
title No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
title_full No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
title_fullStr No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
title_full_unstemmed No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
title_short No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
title_sort no association between val158met of the comt gene and susceptibility to schizophrenia in the syrian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336908/
https://www.ncbi.nlm.nih.gov/pubmed/22540087
http://dx.doi.org/10.4297/najms.2011.3176
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