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Microtubule dynamics in the peripheral nervous system: A matter of balance
The special architecture of neurons in the peripheral nervous system, with axons extending for long distances, represents a major challenge for the intracellular transport system. Two recent studies show that mutations in the small heat shock protein HSPB1, which cause an axonal type of Charcot-Mari...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337128/ https://www.ncbi.nlm.nih.gov/pubmed/22545178 http://dx.doi.org/10.4161/bioa.1.6.19198 |
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author | Almeida-Souza, Leonardo Timmerman, Vincent Janssens, Sophie |
author_facet | Almeida-Souza, Leonardo Timmerman, Vincent Janssens, Sophie |
author_sort | Almeida-Souza, Leonardo |
collection | PubMed |
description | The special architecture of neurons in the peripheral nervous system, with axons extending for long distances, represents a major challenge for the intracellular transport system. Two recent studies show that mutations in the small heat shock protein HSPB1, which cause an axonal type of Charcot-Marie-Tooth (CMT) neuropathy, affect microtubule dynamics and impede axonal transport. Intriguingly, while at presymptomatic age the neurons in the mutant HSPB1 mouse show a hyperstable microtubule network, at postsymptomatic age, the microtubule network completely lost its stability as reflected by a marked decrease in tubulin acetylation levels. We here propose a model explaining the role of microtubule stabilization and tubulin acetylation in the pathogenesis of HSPB1 mutations. |
format | Online Article Text |
id | pubmed-3337128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-33371282012-05-07 Microtubule dynamics in the peripheral nervous system: A matter of balance Almeida-Souza, Leonardo Timmerman, Vincent Janssens, Sophie Bioarchitecture Perspective The special architecture of neurons in the peripheral nervous system, with axons extending for long distances, represents a major challenge for the intracellular transport system. Two recent studies show that mutations in the small heat shock protein HSPB1, which cause an axonal type of Charcot-Marie-Tooth (CMT) neuropathy, affect microtubule dynamics and impede axonal transport. Intriguingly, while at presymptomatic age the neurons in the mutant HSPB1 mouse show a hyperstable microtubule network, at postsymptomatic age, the microtubule network completely lost its stability as reflected by a marked decrease in tubulin acetylation levels. We here propose a model explaining the role of microtubule stabilization and tubulin acetylation in the pathogenesis of HSPB1 mutations. Landes Bioscience 2011-11-01 /pmc/articles/PMC3337128/ /pubmed/22545178 http://dx.doi.org/10.4161/bioa.1.6.19198 Text en Copyright © 2011 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Perspective Almeida-Souza, Leonardo Timmerman, Vincent Janssens, Sophie Microtubule dynamics in the peripheral nervous system: A matter of balance |
title | Microtubule dynamics in the peripheral nervous system: A matter of balance |
title_full | Microtubule dynamics in the peripheral nervous system: A matter of balance |
title_fullStr | Microtubule dynamics in the peripheral nervous system: A matter of balance |
title_full_unstemmed | Microtubule dynamics in the peripheral nervous system: A matter of balance |
title_short | Microtubule dynamics in the peripheral nervous system: A matter of balance |
title_sort | microtubule dynamics in the peripheral nervous system: a matter of balance |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337128/ https://www.ncbi.nlm.nih.gov/pubmed/22545178 http://dx.doi.org/10.4161/bioa.1.6.19198 |
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