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TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses

Synaptic function in the central nervous system (CNS) is highly dependent on a dynamic actin cytoskeleton in both the pre- and the postsynaptic compartment. Remodelling of the actin cytoskeleton is controlled by tropomyosins, a family of actin-associated proteins which define distinct actin filament...

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Detalles Bibliográficos
Autores principales: Guven, Kim, Gunning, Peter, Fath, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337131/
https://www.ncbi.nlm.nih.gov/pubmed/22545181
http://dx.doi.org/10.4161/bioa.1.6.19336
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author Guven, Kim
Gunning, Peter
Fath, Thomas
author_facet Guven, Kim
Gunning, Peter
Fath, Thomas
author_sort Guven, Kim
collection PubMed
description Synaptic function in the central nervous system (CNS) is highly dependent on a dynamic actin cytoskeleton in both the pre- and the postsynaptic compartment. Remodelling of the actin cytoskeleton is controlled by tropomyosins, a family of actin-associated proteins which define distinct actin filament populations. Here we show that TPM3 and TPM4 gene products localize to the postsynaptic region in mouse hippocampal neurons. Furthermore our data confirm previous findings of isoform segregation to the pre- and postsynaptic compartments at CNS synapses. These data provide fundamental insights in the formation of functionally distinct actin filament populations at the pre- and post-synapse.
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spelling pubmed-33371312012-05-07 TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses Guven, Kim Gunning, Peter Fath, Thomas Bioarchitecture Short Communication Synaptic function in the central nervous system (CNS) is highly dependent on a dynamic actin cytoskeleton in both the pre- and the postsynaptic compartment. Remodelling of the actin cytoskeleton is controlled by tropomyosins, a family of actin-associated proteins which define distinct actin filament populations. Here we show that TPM3 and TPM4 gene products localize to the postsynaptic region in mouse hippocampal neurons. Furthermore our data confirm previous findings of isoform segregation to the pre- and postsynaptic compartments at CNS synapses. These data provide fundamental insights in the formation of functionally distinct actin filament populations at the pre- and post-synapse. Landes Bioscience 2011-11-01 /pmc/articles/PMC3337131/ /pubmed/22545181 http://dx.doi.org/10.4161/bioa.1.6.19336 Text en Copyright © 2011 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Short Communication
Guven, Kim
Gunning, Peter
Fath, Thomas
TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses
title TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses
title_full TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses
title_fullStr TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses
title_full_unstemmed TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses
title_short TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses
title_sort tpm3 and tpm4 gene products segregate to the postsynaptic region of central nervous system synapses
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337131/
https://www.ncbi.nlm.nih.gov/pubmed/22545181
http://dx.doi.org/10.4161/bioa.1.6.19336
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