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Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility

In vitro fertilization (IVF) is a risk factor for pregnancy, but there have been few studies on the effect of infertility's aetiology. Thus, we have assessed the role of aetiology on IVF pregnancy outcomes in a retrospective cohort study comparing the outcomes of IVF singleton pregnancies with...

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Autores principales: Kuivasaari-Pirinen, Paula, Raatikainen, Kaisa, Hippeläinen, Maritta, Heinonen, Seppo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337484/
https://www.ncbi.nlm.nih.gov/pubmed/22570795
http://dx.doi.org/10.5402/2012/451915
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author Kuivasaari-Pirinen, Paula
Raatikainen, Kaisa
Hippeläinen, Maritta
Heinonen, Seppo
author_facet Kuivasaari-Pirinen, Paula
Raatikainen, Kaisa
Hippeläinen, Maritta
Heinonen, Seppo
author_sort Kuivasaari-Pirinen, Paula
collection PubMed
description In vitro fertilization (IVF) is a risk factor for pregnancy, but there have been few studies on the effect of infertility's aetiology. Thus, we have assessed the role of aetiology on IVF pregnancy outcomes in a retrospective cohort study comparing the outcomes of IVF singleton pregnancies with those of spontaneous pregnancies in the general Finnish population. The study group consisted of 255 women with births resulting from singleton IVF pregnancies. Six subgroups were formed according to the following causes of infertility: anovulation (27%), endometriosis (19%), male factor (17%), tubal factor (15%), polycystic ovary syndrome (11%), and unexplained infertility (12%). The reference group consisted of 26,870 naturally conceived women. Adjusted odds ratios (AORs), for confounding factors such as age and parity, were estimated using logistic regression analysis. Women with endometriosis and anovulation had increased risks of preterm birth (AOR 3.25, 95% CI 1.5–7.1 and AOR 2.1, and 95% CI 1.0–4.2, resp.), while women in couples with male factor infertility had a twofold risk of admission to neonatal intensive care (AOR 2.5, 95% CI 1.2–5.3). The findings show that the aetiology of infertility influenced the obstetrics outcome, and that pooling results may obscure some increased risks among subgroups.
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spelling pubmed-33374842012-05-08 Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility Kuivasaari-Pirinen, Paula Raatikainen, Kaisa Hippeläinen, Maritta Heinonen, Seppo ISRN Obstet Gynecol Clinical Study In vitro fertilization (IVF) is a risk factor for pregnancy, but there have been few studies on the effect of infertility's aetiology. Thus, we have assessed the role of aetiology on IVF pregnancy outcomes in a retrospective cohort study comparing the outcomes of IVF singleton pregnancies with those of spontaneous pregnancies in the general Finnish population. The study group consisted of 255 women with births resulting from singleton IVF pregnancies. Six subgroups were formed according to the following causes of infertility: anovulation (27%), endometriosis (19%), male factor (17%), tubal factor (15%), polycystic ovary syndrome (11%), and unexplained infertility (12%). The reference group consisted of 26,870 naturally conceived women. Adjusted odds ratios (AORs), for confounding factors such as age and parity, were estimated using logistic regression analysis. Women with endometriosis and anovulation had increased risks of preterm birth (AOR 3.25, 95% CI 1.5–7.1 and AOR 2.1, and 95% CI 1.0–4.2, resp.), while women in couples with male factor infertility had a twofold risk of admission to neonatal intensive care (AOR 2.5, 95% CI 1.2–5.3). The findings show that the aetiology of infertility influenced the obstetrics outcome, and that pooling results may obscure some increased risks among subgroups. International Scholarly Research Network 2012-04-09 /pmc/articles/PMC3337484/ /pubmed/22570795 http://dx.doi.org/10.5402/2012/451915 Text en Copyright © 2012 Paula Kuivasaari-Pirinen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Kuivasaari-Pirinen, Paula
Raatikainen, Kaisa
Hippeläinen, Maritta
Heinonen, Seppo
Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility
title Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility
title_full Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility
title_fullStr Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility
title_full_unstemmed Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility
title_short Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility
title_sort adverse outcomes of ivf/icsi pregnancies vary depending on aetiology of infertility
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337484/
https://www.ncbi.nlm.nih.gov/pubmed/22570795
http://dx.doi.org/10.5402/2012/451915
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