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Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis
Cutaneous leishmaniasis affects millions of people around the world. Several species of Leishmania infect mouse strains, and murine models closely reproduce the cutaneous lesions caused by the parasite in humans. Mouse models have enabled studies on the pathogenesis and effector mechanisms of host r...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337613/ https://www.ncbi.nlm.nih.gov/pubmed/22570765 http://dx.doi.org/10.1155/2012/203818 |
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author | Horta, Maria Fátima Mendes, Bárbara Pinheiro Roma, Eric Henrique Noronha, Fátima Soares Motta Macêdo, Juan Pereira Oliveira, Luciana Souza Duarte, Myrian Morato Vieira, Leda Quercia |
author_facet | Horta, Maria Fátima Mendes, Bárbara Pinheiro Roma, Eric Henrique Noronha, Fátima Soares Motta Macêdo, Juan Pereira Oliveira, Luciana Souza Duarte, Myrian Morato Vieira, Leda Quercia |
author_sort | Horta, Maria Fátima |
collection | PubMed |
description | Cutaneous leishmaniasis affects millions of people around the world. Several species of Leishmania infect mouse strains, and murine models closely reproduce the cutaneous lesions caused by the parasite in humans. Mouse models have enabled studies on the pathogenesis and effector mechanisms of host resistance to infection. Here, we review the role of nitric oxide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO(−)) in the control of parasites by macrophages, which are both the host cells and the effector cells. We also discuss the role of neutrophil-derived oxygen and nitrogen reactive species during infection with Leishmania. We emphasize the role of these cells in the outcome of leishmaniasis early after infection, before the adaptive T(h)-cell immune response. |
format | Online Article Text |
id | pubmed-3337613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33376132012-05-08 Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis Horta, Maria Fátima Mendes, Bárbara Pinheiro Roma, Eric Henrique Noronha, Fátima Soares Motta Macêdo, Juan Pereira Oliveira, Luciana Souza Duarte, Myrian Morato Vieira, Leda Quercia J Parasitol Res Review Article Cutaneous leishmaniasis affects millions of people around the world. Several species of Leishmania infect mouse strains, and murine models closely reproduce the cutaneous lesions caused by the parasite in humans. Mouse models have enabled studies on the pathogenesis and effector mechanisms of host resistance to infection. Here, we review the role of nitric oxide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO(−)) in the control of parasites by macrophages, which are both the host cells and the effector cells. We also discuss the role of neutrophil-derived oxygen and nitrogen reactive species during infection with Leishmania. We emphasize the role of these cells in the outcome of leishmaniasis early after infection, before the adaptive T(h)-cell immune response. Hindawi Publishing Corporation 2012 2012-04-12 /pmc/articles/PMC3337613/ /pubmed/22570765 http://dx.doi.org/10.1155/2012/203818 Text en Copyright © 2012 Maria Fátima Horta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Horta, Maria Fátima Mendes, Bárbara Pinheiro Roma, Eric Henrique Noronha, Fátima Soares Motta Macêdo, Juan Pereira Oliveira, Luciana Souza Duarte, Myrian Morato Vieira, Leda Quercia Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis |
title | Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis |
title_full | Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis |
title_fullStr | Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis |
title_full_unstemmed | Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis |
title_short | Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis |
title_sort | reactive oxygen species and nitric oxide in cutaneous leishmaniasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337613/ https://www.ncbi.nlm.nih.gov/pubmed/22570765 http://dx.doi.org/10.1155/2012/203818 |
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