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Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Cannabinoids are considered as key mediators in the pathophysiology of inflammatory diseases, including atherosclerosis. In particular, they have been shown to reduce the ischemic injury after acute cardiovascular events, such as acute myocardial infarction and ischemic stroke. These protective and...

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Autores principales: Capettini, Luciano S. A., Savergnini, Silvia Q., da Silva, Rafaela F., Stergiopulos, Nikos, Santos, Robson A. S., Mach, François, Montecucco, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337695/
https://www.ncbi.nlm.nih.gov/pubmed/22577257
http://dx.doi.org/10.1155/2012/824093
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author Capettini, Luciano S. A.
Savergnini, Silvia Q.
da Silva, Rafaela F.
Stergiopulos, Nikos
Santos, Robson A. S.
Mach, François
Montecucco, Fabrizio
author_facet Capettini, Luciano S. A.
Savergnini, Silvia Q.
da Silva, Rafaela F.
Stergiopulos, Nikos
Santos, Robson A. S.
Mach, François
Montecucco, Fabrizio
author_sort Capettini, Luciano S. A.
collection PubMed
description Cannabinoids are considered as key mediators in the pathophysiology of inflammatory diseases, including atherosclerosis. In particular, they have been shown to reduce the ischemic injury after acute cardiovascular events, such as acute myocardial infarction and ischemic stroke. These protective and anti-inflammatory properties on peripheral tissues and circulating inflammatory have been demonstrated to involve their binding with both selective cannabinoid type 1 (CB(1)) and type 2 (CB(2)) transmembrane receptors. On the other hands, the recent discoveries of novel different classes of cannabinoids and receptors have increased the complexity of this system in atherosclerosis. Although only preliminary data have been reported on the activities of novel cannabinoid receptors, several studies have already investigated the role of CB(1) and CB(2) receptors in ischemic stroke. While CB(1) receptor activation has been shown to directly reduce atherosclerotic plaque inflammation, controversial data have been shown on neurotransmission and neuroprotection after stroke. Given its potent anti-inflammatory activities on circulating leukocytes, the CB(2) activation has been proven to produce protective effects against acute poststroke inflammation. In this paper, we will update evidence on different cannabinoid-triggered avenues to reduce inflammation and neuronal injury in acute ischemic stroke.
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spelling pubmed-33376952012-05-10 Update on the Role of Cannabinoid Receptors after Ischemic Stroke Capettini, Luciano S. A. Savergnini, Silvia Q. da Silva, Rafaela F. Stergiopulos, Nikos Santos, Robson A. S. Mach, François Montecucco, Fabrizio Mediators Inflamm Review Article Cannabinoids are considered as key mediators in the pathophysiology of inflammatory diseases, including atherosclerosis. In particular, they have been shown to reduce the ischemic injury after acute cardiovascular events, such as acute myocardial infarction and ischemic stroke. These protective and anti-inflammatory properties on peripheral tissues and circulating inflammatory have been demonstrated to involve their binding with both selective cannabinoid type 1 (CB(1)) and type 2 (CB(2)) transmembrane receptors. On the other hands, the recent discoveries of novel different classes of cannabinoids and receptors have increased the complexity of this system in atherosclerosis. Although only preliminary data have been reported on the activities of novel cannabinoid receptors, several studies have already investigated the role of CB(1) and CB(2) receptors in ischemic stroke. While CB(1) receptor activation has been shown to directly reduce atherosclerotic plaque inflammation, controversial data have been shown on neurotransmission and neuroprotection after stroke. Given its potent anti-inflammatory activities on circulating leukocytes, the CB(2) activation has been proven to produce protective effects against acute poststroke inflammation. In this paper, we will update evidence on different cannabinoid-triggered avenues to reduce inflammation and neuronal injury in acute ischemic stroke. Hindawi Publishing Corporation 2012 2012-04-05 /pmc/articles/PMC3337695/ /pubmed/22577257 http://dx.doi.org/10.1155/2012/824093 Text en Copyright © 2012 Luciano S. A. Capettini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Capettini, Luciano S. A.
Savergnini, Silvia Q.
da Silva, Rafaela F.
Stergiopulos, Nikos
Santos, Robson A. S.
Mach, François
Montecucco, Fabrizio
Update on the Role of Cannabinoid Receptors after Ischemic Stroke
title Update on the Role of Cannabinoid Receptors after Ischemic Stroke
title_full Update on the Role of Cannabinoid Receptors after Ischemic Stroke
title_fullStr Update on the Role of Cannabinoid Receptors after Ischemic Stroke
title_full_unstemmed Update on the Role of Cannabinoid Receptors after Ischemic Stroke
title_short Update on the Role of Cannabinoid Receptors after Ischemic Stroke
title_sort update on the role of cannabinoid receptors after ischemic stroke
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337695/
https://www.ncbi.nlm.nih.gov/pubmed/22577257
http://dx.doi.org/10.1155/2012/824093
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