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Major Functional Transcriptome of an Inferred Center Regulator of an ER(−) Breast Cancer Model System
We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(−) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 networ...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337785/ https://www.ncbi.nlm.nih.gov/pubmed/22553414 http://dx.doi.org/10.4137/CIN.S8633 |
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author | Liu, Li-Yu Daisy Chang, Li-Yun Kuo, Wen-Hung Hwa, Hsiao-Lin Lin, Yi-Shing Huang, Shiu-Feng Chen, Chiung-Nien Chang, King-Jen Hsieh, Fon-Jou |
author_facet | Liu, Li-Yu Daisy Chang, Li-Yun Kuo, Wen-Hung Hwa, Hsiao-Lin Lin, Yi-Shing Huang, Shiu-Feng Chen, Chiung-Nien Chang, King-Jen Hsieh, Fon-Jou |
author_sort | Liu, Li-Yu Daisy |
collection | PubMed |
description | We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(−) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 network. MYC and STAT3 may co-regulate gene expressions for Warburg effect, stem cell like phenotype, cell proliferation and angiogenesis. We identified a STAT3 network in silico showing its ability in predicting its target gene expressions primarily for specific tumor subtype, tumor progression, treatment options and prognostic features. The aberrant expressions of MYC and STAT3 are enriched in triple negatives (TN). They promote histological grade, vascularity, metastasis and tumor anti-apoptotic activities. VEGFA, STAT3, FOXM1 and METAP2 are druggable targets. High levels of METAP2, MMP7, IGF2 and IGF2R are unfavorable prognostic factors. STAT3 is an inferred center regulator at early cancer development predominantly in TN. |
format | Online Article Text |
id | pubmed-3337785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-33377852012-05-02 Major Functional Transcriptome of an Inferred Center Regulator of an ER(−) Breast Cancer Model System Liu, Li-Yu Daisy Chang, Li-Yun Kuo, Wen-Hung Hwa, Hsiao-Lin Lin, Yi-Shing Huang, Shiu-Feng Chen, Chiung-Nien Chang, King-Jen Hsieh, Fon-Jou Cancer Inform Rapid Communication We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(−) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 network. MYC and STAT3 may co-regulate gene expressions for Warburg effect, stem cell like phenotype, cell proliferation and angiogenesis. We identified a STAT3 network in silico showing its ability in predicting its target gene expressions primarily for specific tumor subtype, tumor progression, treatment options and prognostic features. The aberrant expressions of MYC and STAT3 are enriched in triple negatives (TN). They promote histological grade, vascularity, metastasis and tumor anti-apoptotic activities. VEGFA, STAT3, FOXM1 and METAP2 are druggable targets. High levels of METAP2, MMP7, IGF2 and IGF2R are unfavorable prognostic factors. STAT3 is an inferred center regulator at early cancer development predominantly in TN. Libertas Academica 2012-04-19 /pmc/articles/PMC3337785/ /pubmed/22553414 http://dx.doi.org/10.4137/CIN.S8633 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. |
spellingShingle | Rapid Communication Liu, Li-Yu Daisy Chang, Li-Yun Kuo, Wen-Hung Hwa, Hsiao-Lin Lin, Yi-Shing Huang, Shiu-Feng Chen, Chiung-Nien Chang, King-Jen Hsieh, Fon-Jou Major Functional Transcriptome of an Inferred Center Regulator of an ER(−) Breast Cancer Model System |
title | Major Functional Transcriptome of an Inferred Center Regulator of an ER(−) Breast Cancer Model System |
title_full | Major Functional Transcriptome of an Inferred Center Regulator of an ER(−) Breast Cancer Model System |
title_fullStr | Major Functional Transcriptome of an Inferred Center Regulator of an ER(−) Breast Cancer Model System |
title_full_unstemmed | Major Functional Transcriptome of an Inferred Center Regulator of an ER(−) Breast Cancer Model System |
title_short | Major Functional Transcriptome of an Inferred Center Regulator of an ER(−) Breast Cancer Model System |
title_sort | major functional transcriptome of an inferred center regulator of an er(−) breast cancer model system |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337785/ https://www.ncbi.nlm.nih.gov/pubmed/22553414 http://dx.doi.org/10.4137/CIN.S8633 |
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