Cargando…

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

The accumulation of amyloid-β in the brain is an essential feature of Alzheimer's disease. However, the impact of amyloid-β-accumulation on neuronal dysfunction on the single cell level in vivo is poorly understood. Here we investigate the progression of amyloid-β load in relation to neuronal d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grienberger, Christine, Rochefort, Nathalie L., Adelsberger, Helmuth, Henning, Horst A., Hill, Daniel N., Reichwald, Julia, Staufenbiel, Matthias, Konnerth, Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337977/ https://www.ncbi.nlm.nih.gov/pubmed/22491322 http://dx.doi.org/10.1038/ncomms1783

Ejemplares similares

Expression of complement system components during aging and amyloid deposition in APP transgenic mice
por: Reichwald, Julia, et al.
Publicado: (2009)

Levetiracetam alleviates cognitive decline in Alzheimer’s disease animal model by ameliorating the dysfunction of the neuronal network
por: Zheng, Xiang-Yu, et al.
Publicado: (2022)

Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β
por: Schonrock, Nicole, et al.
Publicado: (2010)

In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb
por: Homma, R., et al.
Publicado: (2013)

In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors
por: Song, Beomjong, et al.
Publicado: (2021)

Neuronal-Derived EV Biomarkers Track Cognitive Decline in Alzheimer’s Disease
por: Eren, Erden, et al.
Publicado: (2022)

No effect of thyroid hormones on 5‐year mortality in patients with subjective cognitive decline, mild cognitive disorder, and Alzheimer’s disease
por: Đapić, Blaž, et al.
Publicado: (2022)

Action and learning shape the activity of neuronal circuits in the visual cortex
por: Pakan, Janelle MP, et al.
Publicado: (2018)

Parametric Copula-GP model for analyzing multidimensional neuronal and behavioral relationships
por: Kudryashova, Nina, et al.
Publicado: (2022)

In vivo tau staging in Alzheimer’s disease
por: Therriault, Joseph, et al.
Publicado: (2022)

Comparative Evaluation of the Gut Microbiota Associated with the Below- and Above-Ground Life Stages (Larvae and Beetles) of the Forest Cockchafer, Melolontha hippocastani
por: Arias-Cordero, Erika, et al.
Publicado: (2012)

Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models
por: Maia, Luis F, et al.
Publicado: (2015)

High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion
por: Francioni, Valerio, et al.
Publicado: (2019)

Genetic effects on longitudinal cognitive decline during the early stages of Alzheimer’s disease
por: Kumar, Atul, et al.
Publicado: (2021)

Deciphering the Molecular Profile of Plaques, Memory Decline and Neuron Loss in Two Mouse Models for Alzheimer’s Disease by Deep Sequencing
por: Bouter, Yvonne, et al.
Publicado: (2014)

Synaptic dynamics and neuronal network connectivity are reflected in the distribution of times in Up states
por: Dao Duc, Khanh, et al.
Publicado: (2015)

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins
por: Avila, Jesús, et al.
Publicado: (2017)

Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer’s disease mutations
por: Keramidis, Iason, et al.
Publicado: (2023)

Entorhinal cortex directs learning-related changes in CA1 representations
por: Grienberger, Christine, et al.
Publicado: (2022)

Author Correction: Entorhinal cortex directs learning-related changes in CA1 representations
por: Grienberger, Christine, et al.
Publicado: (2022)

Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer’s disease
por: Pillai, Jagan A., et al.
Publicado: (2020)

Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
por: Balakrishnan, Karthikeyan, et al.
Publicado: (2015)

Two types of functionally distinct Ca(2+) stores in hippocampal neurons
por: Chen-Engerer, Hsing-Jung, et al.
Publicado: (2019)

Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals
por: Biel, Davina, et al.
Publicado: (2021)

Impairment of Adolescent Hippocampal Plasticity in a Mouse Model for Alzheimer's Disease Precedes Disease Phenotype
por: Hartl, Daniela, et al.
Publicado: (2008)

Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of β-Secretase in a Mouse Model of Alzheimer’s Disease
por: He, Ping, et al.
Publicado: (2013)

Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons
por: Sutherland, Theresa C., et al.
Publicado: (2021)

Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer’s Disease
por: Tsai, Yueh-Ting, et al.
Publicado: (2022)

Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease
por: Pillai, Jagan A., et al.
Publicado: (2023)

Prospective Associations between Single Foods, Alzheimer’s Dementia and Memory Decline in the Elderly
por: Fischer, Karina, et al.
Publicado: (2018)

Cognitive Declines Precede and Predict Functional Declines in Aging and Alzheimer’s Disease
por: Zahodne, Laura B., et al.
Publicado: (2013)

Periodontitis and Cognitive Decline in Alzheimer’s Disease
por: Ide, Mark, et al.
Publicado: (2016)

Is the risk of Alzheimer’s disease and dementia declining?
por: Langa, Kenneth M
Publicado: (2015)

Reversal of cognitive decline in Alzheimer's disease
por: Bredesen, Dale E., et al.
Publicado: (2016)

Cognitive Decline: Not Always Alzheimer’s Disease
por: Villalba, Noel Lorenzo, et al.
Publicado: (2018)

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease
por: Zhang, Liang, et al.
Publicado: (2015)

The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease – Evidence from epidemiological and animal studies
por: Kilian, Jason, et al.
Publicado: (2018)

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model
por: Ankul, Singh S., et al.
Publicado: (2023)

Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons
por: Bittner, Katie C., et al.
Publicado: (2015)

CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease
por: Westin, Karin, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_jh7kjgh7tvkm5eiqmigimefleb