BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

By diversifying antibody biological effector functions, class switch DNA recombination has a central role in the maturation of the antibody response. Here we show that BCR-signalling synergizes with Toll-like receptor (TLR) signalling to induce class switch DNA recombination. BCR-signalling activate...

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Detalles Bibliográficos
Autores principales: Pone, Egest J., Zhang, Jinsong, Mai, Thach, White, Clayton A., Li, Guideng, Sakakura, John K., Patel, Pina J., Al-Qahtani, Ahmed, Zan, Hong, Xu, Zhenming, Casali, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337981/
https://www.ncbi.nlm.nih.gov/pubmed/22473011
http://dx.doi.org/10.1038/ncomms1769

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