HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma

In this study 15 banked samples of HIV-related Non-Hodgkin's Lymphoma (NHL) cases were tested for HIV co-receptor usage and SDF1 3'A polymorphism. Reportable tropism from 9 plasma samples had 1 (11.1%) HIV case with CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the cases occurre...

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Autores principales: Reid, Erin, Morris, Sheldon R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338399/
https://www.ncbi.nlm.nih.gov/pubmed/22420651
http://dx.doi.org/10.1186/1750-9378-7-6
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author Reid, Erin
Morris, Sheldon R
author_facet Reid, Erin
Morris, Sheldon R
author_sort Reid, Erin
collection PubMed
description In this study 15 banked samples of HIV-related Non-Hodgkin's Lymphoma (NHL) cases were tested for HIV co-receptor usage and SDF1 3'A polymorphism. Reportable tropism from 9 plasma samples had 1 (11.1%) HIV case with CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the cases occurred at a late stage of HIV (2/3 had CD4 counts below 200), where expected CXCR4 usage would be 60%. Based on the expected proportion of less than 50% CCR5 in chronically infected individuals, this would suggest that in NHL may be associated with CCR5 usage (P = 0.04).
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spelling pubmed-33383992012-04-28 HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma Reid, Erin Morris, Sheldon R Infect Agent Cancer Letter to the Editor In this study 15 banked samples of HIV-related Non-Hodgkin's Lymphoma (NHL) cases were tested for HIV co-receptor usage and SDF1 3'A polymorphism. Reportable tropism from 9 plasma samples had 1 (11.1%) HIV case with CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the cases occurred at a late stage of HIV (2/3 had CD4 counts below 200), where expected CXCR4 usage would be 60%. Based on the expected proportion of less than 50% CCR5 in chronically infected individuals, this would suggest that in NHL may be associated with CCR5 usage (P = 0.04). BioMed Central 2012-03-15 /pmc/articles/PMC3338399/ /pubmed/22420651 http://dx.doi.org/10.1186/1750-9378-7-6 Text en Copyright ©2012 Reid and Morris; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Reid, Erin
Morris, Sheldon R
HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma
title HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma
title_full HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma
title_fullStr HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma
title_full_unstemmed HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma
title_short HIV Co-receptor usage in HIV-related non-hodgkin's lymphoma
title_sort hiv co-receptor usage in hiv-related non-hodgkin's lymphoma
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338399/
https://www.ncbi.nlm.nih.gov/pubmed/22420651
http://dx.doi.org/10.1186/1750-9378-7-6
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