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NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice
NK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute induced disease models of diabetes. Yet, the role of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338490/ https://www.ncbi.nlm.nih.gov/pubmed/22558306 http://dx.doi.org/10.1371/journal.pone.0036011 |
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author | Beilke, Joshua N. Meagher, Craig T. Hosiawa, Karoline Champsaur, Marine Bluestone, Jeffrey A. Lanier, Lewis L. |
author_facet | Beilke, Joshua N. Meagher, Craig T. Hosiawa, Karoline Champsaur, Marine Bluestone, Jeffrey A. Lanier, Lewis L. |
author_sort | Beilke, Joshua N. |
collection | PubMed |
description | NK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute induced disease models of diabetes. Yet, the role of NK cells in spontaneous diabetes has not been directly addressed. Here, we used the NOD.NK1.1 congenic mouse model to examine the role of NK cells in spontaneous diabetes. Significant numbers of NK cells were only seen in the pancreas of mice with disease. Pancreatic NK cells displayed an activated surface phenotype and proliferated more than NK cells from other tissues in the diseased mice. Nonetheless, depletion of NK cells had no effect on dendritic cell maturation or T cell proliferation. In spontaneous disease, the deletion of NK cells had no significant impact on disease onset. NK cells were also not required to promote disease induced by adoptively transferred pathogenic CD4(+) T cells. Thus, NK cells are not required for spontaneous autoimmune diabetes in NOD mice. |
format | Online Article Text |
id | pubmed-3338490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33384902012-05-03 NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice Beilke, Joshua N. Meagher, Craig T. Hosiawa, Karoline Champsaur, Marine Bluestone, Jeffrey A. Lanier, Lewis L. PLoS One Research Article NK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute induced disease models of diabetes. Yet, the role of NK cells in spontaneous diabetes has not been directly addressed. Here, we used the NOD.NK1.1 congenic mouse model to examine the role of NK cells in spontaneous diabetes. Significant numbers of NK cells were only seen in the pancreas of mice with disease. Pancreatic NK cells displayed an activated surface phenotype and proliferated more than NK cells from other tissues in the diseased mice. Nonetheless, depletion of NK cells had no effect on dendritic cell maturation or T cell proliferation. In spontaneous disease, the deletion of NK cells had no significant impact on disease onset. NK cells were also not required to promote disease induced by adoptively transferred pathogenic CD4(+) T cells. Thus, NK cells are not required for spontaneous autoimmune diabetes in NOD mice. Public Library of Science 2012-04-25 /pmc/articles/PMC3338490/ /pubmed/22558306 http://dx.doi.org/10.1371/journal.pone.0036011 Text en Beilke et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Beilke, Joshua N. Meagher, Craig T. Hosiawa, Karoline Champsaur, Marine Bluestone, Jeffrey A. Lanier, Lewis L. NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice |
title | NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice |
title_full | NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice |
title_fullStr | NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice |
title_full_unstemmed | NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice |
title_short | NK Cells Are Not Required for Spontaneous Autoimmune Diabetes in NOD Mice |
title_sort | nk cells are not required for spontaneous autoimmune diabetes in nod mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338490/ https://www.ncbi.nlm.nih.gov/pubmed/22558306 http://dx.doi.org/10.1371/journal.pone.0036011 |
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