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Sphingomyelinase D Activity in Model Membranes: Structural Effects of in situ Generation of Ceramide-1-Phosphate

The toxicity of Loxosceles spider venom has been attributed to a rare enzyme, sphingomyelinase D, which transforms sphingomyelin to ceramide-1-phosphate. The bases of its inflammatory and dermonecrotic activity, however, remain unclear. In this work the effects of ceramide-1-phosphate on model membr...

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Detalles Bibliográficos
Autores principales:	Stock, Roberto P., Brewer, Jonathan, Wagner, Kerstin, Ramos-Cerrillo, Blanca, Duelund, Lars, Jernshøj, Kit Drescher, Olsen, Lars Folke, Bagatolli, Luis A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338491/ https://www.ncbi.nlm.nih.gov/pubmed/22558302 http://dx.doi.org/10.1371/journal.pone.0036003

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