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Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin

Low extracellular pH (pH(e)), that is characteristic of many tumours, tends to reduce the uptake of weakly basic drugs, such as doxorubicin, thereby conferring a degree of physiological resistance to chemotherapy. It has been assumed, from pH-partition theory, that the effect of intracellular pH (pH...

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Detalles Bibliográficos
Autores principales:	Swietach, Pawel, Hulikova, Alzbeta, Patiar, Shalini, Vaughan-Jones, Richard D., Harris, Adrian L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338554/ https://www.ncbi.nlm.nih.gov/pubmed/22563426 http://dx.doi.org/10.1371/journal.pone.0035949

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