Cargando…

YopJ-Induced Caspase-1 Activation in Yersinia-Infected Macrophages: Independent of Apoptosis, Linked to Necrosis, Dispensable for Innate Host Defense

Yersinia outer protein J (YopJ) is a type III secretion system (T3SS) effector of pathogenic Yersinia (Yersinia pestis, Yersinia enterocolitica and Yersinia pseudotuberculosis) that is secreted into host cells. YopJ inhibits survival response pathways in macrophages, causing cell death. Allelic vari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Ying, Lilo, Sarit, Mena, Patricio, Bliska, James B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338577/ https://www.ncbi.nlm.nih.gov/pubmed/22563435 http://dx.doi.org/10.1371/journal.pone.0036019

Ejemplares similares

Structural Requirements for Yersinia YopJ Inhibition of MAP Kinase Pathways
por: Hao, Yi-Heng, et al.
Publicado: (2008)

Heightened Virulence of Yersinia Is Associated with Decreased Function of the YopJ Protein
por: Mares, Chris A., et al.
Publicado: (2021)

γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans
por: Chu, Timothy H., et al.
Publicado: (2021)

Reduced Secretion of YopJ by Yersinia Limits In Vivo Cell Death but Enhances Bacterial Virulence
por: Brodsky, Igor E., et al.
Publicado: (2008)

Correction: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans
por: Chu, Timothy H., et al.
Publicado: (2022)

Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation
por: Zhou, Honglin, et al.
Publicado: (2005)

The Acetyltransferase Activity of the Bacterial Toxin YopJ of Yersinia Is Activated by Eukaryotic Host Cell Inositol Hexakisphosphate
por: Mittal, Rohit, et al.
Publicado: (2010)

Mechanism of host substrate acetylation by a YopJ family effector
por: Zhang, Zhi-Min, et al.
Publicado: (2017)

Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase
por: Xia, Yao, et al.
Publicado: (2021)

Neutrophils Are Resistant to Yersinia YopJ/P-Induced Apoptosis and Are Protected from ROS-Mediated Cell Death by the Type III Secretion System
por: Spinner, Justin L., et al.
Publicado: (2010)

Yersinia pseudotuberculosis YopJ Limits Macrophage Response by Downregulating COX-2-Mediated Biosynthesis of PGE2 in a MAPK/ERK-Dependent Manner
por: Sheppe, Austin E. F., et al.
Publicado: (2021)

A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors
por: Bürger, Marco, et al.
Publicado: (2017)

IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM
por: Chung, Lawton K., et al.
Publicado: (2014)

Erratum for Sheppe et al., “Yersinia pseudotuberculosis YopJ Limits Macrophage Response by Downregulating COX-2-Mediated Biosynthesis of PGE2 in a MAPK/ERK-Dependent Manner”
por: Sheppe, Austin E. F., et al.
Publicado: (2023)

The GAP Activity of Type III Effector YopE Triggers Killing of Yersinia in Macrophages
por: Wang, Xiaoying, et al.
Publicado: (2014)

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD
por: Zwack, Erin E., et al.
Publicado: (2015)

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages
por: Zheng, Ying, et al.
Publicado: (2011)

CCR2(+) Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8(+) T Cell Response to the Protective YopE(69-77) Epitope during Yersinia Infection
por: Zhang, Yue, et al.
Publicado: (2015)

Random Mutagenesis Identifies a C-Terminal Region of YopD Important for Yersinia Type III Secretion Function
por: Solomon, Rebecca, et al.
Publicado: (2015)

Caspase-3 Mediates the Pathogenic Effect of Yersinia pestis YopM in Liver of C57BL/6 Mice and Contributes to YopM's Function in Spleen
por: Ye, Zhan, et al.
Publicado: (2014)

Mechanisms of Yersinia YopO kinase substrate specificity
por: Lee, Wei Lin, et al.
Publicado: (2017)

Expression and Association of the Yersinia pestis Translocon Proteins, YopB and YopD, Are Facilitated by Nanolipoprotein Particles
por: Coleman, Matthew A., et al.
Publicado: (2016)

Yersinia enterocolitica Targets Cells of the Innate and Adaptive Immune System by Injection of Yops in a Mouse Infection Model
por: Köberle, Martin, et al.
Publicado: (2009)

LcrG secretion is not required for blocking of Yops secretion in Yersinia pestis
por: Reina, Laura D, et al.
Publicado: (2008)

Characterization of New Substrates Targeted By Yersinia Tyrosine Phosphatase YopH
por: de la Puerta, María Luisa, et al.
Publicado: (2009)

Toward a molecular pathogenic pathway for Yersinia pestis YopM
por: Uittenbogaard, Annette M., et al.
Publicado: (2012)

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
por: Ratner, Dmitry, et al.
Publicado: (2016)

The Yersinia YopE and YopH type III effector proteins enhance bacterial proliferation following contact with eukaryotic cells
por: Bartra, Sara, et al.
Publicado: (2001)

YopN and TyeA Hydrophobic Contacts Required for Regulating Ysc-Yop Type III Secretion Activity by Yersinia pseudotuberculosis
por: Amer, Ayad A. A., et al.
Publicado: (2016)

Macrophage innate immune responses delineate between defective translocon assemblies produced by Yersinia pseudotuberculosis YopD mutants
por: Farag, Salah I., et al.
Publicado: (2023)

The SycN/YscB chaperone-binding domain of YopN is required for the calcium-dependent regulation of Yop secretion by Yersinia pestis
por: Joseph, Sabrina S., et al.
Publicado: (2013)

The Yersinia enterocolitica type three secretion chaperone SycO is integrated into the Yop regulatory network and binds to the Yop secretion protein YscM1
por: Dittmann, Svea, et al.
Publicado: (2007)

Yersinia Virulence Factor YopM Induces Sustained RSK Activation by Interfering with Dephosphorylation
por: Hentschke, Moritz, et al.
Publicado: (2010)

Identification of specific sequence motif of YopN of Yersinia pseudotuberculosis required for systemic infection
por: Bamyaci, Sarp, et al.
Publicado: (2018)

Yersinia enterocolitica YopT and Clostridium difficile Toxin B Induce Expression of GILZ in Epithelial Cells
por: Köberle, Martin, et al.
Publicado: (2012)

Yersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics
por: Singaravelu, Pavithra, et al.
Publicado: (2017)

Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection
por: Shaban, Lamyaa, et al.
Publicado: (2020)

Crystal structure of the Yersinia tyrosine phosphatase
por: Bliska, James B.
Publicado: (1995)

Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells
por: Houppert, Andrew S., et al.
Publicado: (2012)

Adhesins and Host Serum Factors Drive Yop Translocation by Yersinia into Professional Phagocytes during Animal Infection
por: Maldonado-Arocho, Francisco J., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_95koqfgpcm6k0tio4s5q2jktv9