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Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure
Single-minded 1 (Sim1) is a transcription factor necessary for development of the paraventricular nucleus of the hypothalamus (PVH). This nucleus is a critical regulator of appetite, energy expenditure and body weight. Previously we showed that Sim1(+/−) mice and conditional postnatal Sim1(−/−) mice...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338647/ https://www.ncbi.nlm.nih.gov/pubmed/22558467 http://dx.doi.org/10.1371/journal.pone.0036453 |