Cargando…

Mutations of the Mouse ELMO Domain Containing 1 Gene (Elmod1) Link Small GTPase Signaling to Actin Cytoskeleton Dynamics in Hair Cell Stereocilia

Stereocilia, the modified microvilli projecting from the apical surfaces of the sensory hair cells of the inner ear, are essential to the mechanoelectrical transduction process underlying hearing and balance. The actin-filled stereocilia on each hair cell are tethered together by fibrous links to fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnson, Kenneth R., Longo-Guess, Chantal M., Gagnon, Leona H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338648/ https://www.ncbi.nlm.nih.gov/pubmed/22558334 http://dx.doi.org/10.1371/journal.pone.0036074

Ejemplares similares

The organization of actin filaments in the stereocilia of cochlear hair cells
Publicado: (1980)

Actin filaments, stereocilia, and hair cells of the bird cochlea. II. Packing of actin filaments in the stereocilia and in the cuticular plate and what happens to the organization when the stereocilia are bent
Publicado: (1983)

Actin filaments, stereocilia, and hair cells of the bird cochlea. I. Length, number, width, and distribution of stereocilia of each hair cell are related to the position of the hair cell on the cochlea
Publicado: (1983)

Gelsolin Plays a Role in the Actin Polymerization Complex of Hair Cell Stereocilia
por: Mburu, Philomena, et al.
Publicado: (2010)

Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle
por: Pacentine, Itallia, et al.
Publicado: (2020)

Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton
por: Singh, Vikash, et al.
Publicado: (2017)

The Rho GTPase Cell Division Cycle 42 Regulates Stereocilia Development in Cochlear Hair Cells
por: Du, Haibo, et al.
Publicado: (2021)

A shortcut from GPCR signaling to Rac-mediated actin cytoskeleton through an ELMO/DOCK complex
por: Xu, Xuehua, et al.
Publicado: (2012)

β-Actin and γ-Actin Are Each Dispensable for Auditory Hair Cell Development But Required for Stereocilia Maintenance
por: Perrin, Benjamin J., et al.
Publicado: (2010)

An Elmo–Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion
por: Toret, Christopher P., et al.
Publicado: (2014)

FCHSD1 and FCHSD2 Are Expressed in Hair Cell Stereocilia and Cuticular Plate and Regulate Actin Polymerization In Vitro
por: Cao, Huiren, et al.
Publicado: (2013)

The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic
por: Turn, Rachel E., et al.
Publicado: (2022)

TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase
por: Goncharova, Elena, et al.
Publicado: (2004)

An Alteration in ELMOD3, an Arl2 GTPase-Activating Protein, Is Associated with Hearing Impairment in Humans
por: Jaworek, Thomas J., et al.
Publicado: (2013)

The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis
por: Turn, Rachel E., et al.
Publicado: (2020)

ELMO proteins transduce G protein-coupled receptor signal to control reorganization of actin cytoskeleton in chemotaxis of eukaryotic cells
por: Xu, Xuehua, et al.
Publicado: (2017)

Tracing Actin Filament Bundles in Three-Dimensional Electron Tomography Density Maps of Hair Cell Stereocilia
por: Sazzed, Salim, et al.
Publicado: (2018)

Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1 ( −/− ), elmo2 ( −/− ), and elmo3 ( −/− ) Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins
por: Boger, Mike, et al.
Publicado: (2022)

Inner hair cell stereocilia are embedded in the tectorial membrane
por: Hakizimana, Pierre, et al.
Publicado: (2021)

Radixin modulates the function of outer hair cell stereocilia
por: Prasad, Sonal, et al.
Publicado: (2020)

Control of stereocilia length during development of hair bundles
por: Krey, Jocelyn F., et al.
Publicado: (2023)

Actin filaments, stereocilia, and hair cells of the bird cochlea. V. How the staircase pattern of stereociliary lengths is generated
Publicado: (1988)

Roles for ELMOD2 and Rootletin in ciliogenesis
por: Turn, Rachel E., et al.
Publicado: (2021)

The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors
por: Newman, Laura E., et al.
Publicado: (2017)

Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection
por: Wang, Jia-Li, et al.
Publicado: (2010)

Targeting Ras-binding domain of ELMO1 by computational nanobody design
por: Tam, Chunlai, et al.
Publicado: (2023)

Sound-induced length changes in outer hair cell stereocilia
por: Hakizimana, Pierre, et al.
Publicado: (2012)

Polarized condensates confer row identity of hair cell stereocilia
por: Shi, Yingdong, et al.
Publicado: (2022)

Regeneration of Stereocilia of Hair Cells by Forced Atoh1 Expression in the Adult Mammalian Cochlea
por: Yang, Shi-Ming, et al.
Publicado: (2012)

LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice
por: Men, Yuqin, et al.
Publicado: (2015)

CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that target different GTPases
por: Venkatachalam, Thejasvi, et al.
Publicado: (2023)

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid
por: Krey, Jocelyn F., et al.
Publicado: (2016)

P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases
por: Noren, Nicole K., et al.
Publicado: (2000)

The stable actin core of mechanosensory stereocilia features continuous turnover of actin cross-linkers
por: Roy, Pallabi, et al.
Publicado: (2018)

PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing
por: Wu, Xudong, et al.
Publicado: (2019)

Mammalian Abp1, a Signal-Responsive F-Actin–Binding Protein, Links the Actin Cytoskeleton to Endocytosis via the Gtpase Dynamin
por: Kessels, Michael M., et al.
Publicado: (2001)

The actin filament content of hair cells of the bird cochlea is nearly constant even though the length, width, and number of stereocilia vary depending on the hair cell location
Publicado: (1988)

Simulation of the Response of the Inner Hair Cell Stereocilia Bundle to an Acoustical Stimulus
por: Smith, Sonya T., et al.
Publicado: (2011)

Liquid-liquid phase separation in hair cell stereocilia development and maintenance
por: Li, Jianchao
Publicado: (2023)

MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea
por: Ikäheimo, Kuu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dj5af9km1k1h9hm26r1ec1mesv