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The Antibody Targeting the E314 Peptide of Human Kv1.3 Pore Region Serves as a Novel, Potent and Specific Channel Blocker

Selective blockade of Kv1.3 channels in effector memory T (T(EM)) cells was validated to ameliorate autoimmune or autoimmune-associated diseases. We generated the antibody directed against one peptide of human Kv1.3 (hKv1.3) extracellular loop as a novel and possible Kv1.3 blocker. One peptide of hK...

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Detalles Bibliográficos
Autores principales:	Yang, Xiao-Fang, Yang, Yong, Lian, Yi-Tian, Wang, Zhao-Hui, Li, Xiao-Wei, Cheng, Long-Xian, Liu, Jin-Ping, Wang, Yan-Fu, Gao, Xiang, Liao, Yu-Hua, Wang, Min, Zeng, Qiu-Tang, Liu, Kun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338681/ https://www.ncbi.nlm.nih.gov/pubmed/22558454 http://dx.doi.org/10.1371/journal.pone.0036379

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