Cargando…

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants

BACKGROUND: Acid sphingomyelinase (ASM) hydrolyses sphingomyelin and generates the lipid messenger ceramide, which mediates a variety of stress-related cellular processes. The pathological effects of dysregulated ASM activity are evident in several human diseases and indicate an important functional...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rhein, Cosima, Tripal, Philipp, Seebahn, Angela, Konrad, Alice, Kramer, Marcel, Nagel, Christine, Kemper, Jonas, Bode, Jens, Mühle, Christiane, Gulbins, Erich, Reichel, Martin, Becker, Cord-Michael, Kornhuber, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338701/ https://www.ncbi.nlm.nih.gov/pubmed/22558155 http://dx.doi.org/10.1371/journal.pone.0035467

Ejemplares similares

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase
por: Kornhuber, Johannes, et al.
Publicado: (2011)

The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice
por: Zoicas, Iulia, et al.
Publicado: (2020)

Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal Fluid
por: Mühle, Christiane, et al.
Publicado: (2013)

mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment
por: Rhein, Cosima, et al.
Publicado: (2021)

Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory
por: Zoicas, Iulia, et al.
Publicado: (2016)

Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls
por: Mühle, Christiane, et al.
Publicado: (2018)

Alleged Detrimental Mutations in the SMPD1 Gene in Patients with Niemann-Pick Disease
por: Rhein, Cosima, et al.
Publicado: (2015)

Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression
por: Mühle, Christiane, et al.
Publicado: (2019)

The acid sphingomyelinase/ceramide system in COVID-19
por: Kornhuber, Johannes, et al.
Publicado: (2021)

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation
por: Reichel, Martin, et al.
Publicado: (2018)

Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma
por: Mühle, Christiane, et al.
Publicado: (2023)

Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis
por: Müller, Christian P., et al.
Publicado: (2016)

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
por: Beckmann, Nadine, et al.
Publicado: (2014)

Enhanced Alcohol Preference and Anxiolytic Alcohol Effects in Niemann-Pick Disease Model in Mice
por: Kalinichenko, Liubov S., et al.
Publicado: (2019)

Neuroanatomical Correlates of Intelligence in Healthy Young Adults: The Role of Basal Ganglia Volume
por: Rhein, Cosima, et al.
Publicado: (2014)

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
por: Carpinteiro, Alexander, et al.
Publicado: (2021)

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease
por: Beckmann, Nadine, et al.
Publicado: (2019)

Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems
por: Zeitler, Stefanie, et al.
Publicado: (2020)

Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat Brain
por: Zoicas, Iulia, et al.
Publicado: (2020)

Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms
por: Hoertel, Nicolas, et al.
Publicado: (2021)

Staphylococcus aureus α-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell Line
por: Krones, David, et al.
Publicado: (2021)

Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination
por: Chami, Marwan, et al.
Publicado: (2017)

Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
por: Schumacher, Fabian, et al.
Publicado: (2022)

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
por: Carpinteiro, Alexander, et al.
Publicado: (2020)

Regulation of hematogenous tumor metastasis by acid sphingomyelinase
por: Carpinteiro, Alexander, et al.
Publicado: (2015)

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells
por: Avota, Elita, et al.
Publicado: (2011)

Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
por: Wilson, Gregory C., et al.
Publicado: (2023)

Acid Sphingomyelinase Is a Modulator of Contextual Fear
por: Zoicas, Iulia, et al.
Publicado: (2022)

Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study
por: Hoertel, Nicolas, et al.
Publicado: (2023)

Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage
por: Hoehn, Richard S., et al.
Publicado: (2016)

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
por: Kalinichenko, Liubov S., et al.
Publicado: (2021)

Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells
por: Simonis, Alexander, et al.
Publicado: (2014)

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
por: Naser, Eyad, et al.
Publicado: (2020)

New Molecular Targets for Antidepressant Drugs
por: Kornhuber, Johannes, et al.
Publicado: (2021)

Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase
por: Managò, Antonella, et al.
Publicado: (2015)

Identification of Drugs Inducing Phospholipidosis by Novel in vitro Data
por: Muehlbacher, Markus, et al.
Publicado: (2012)

Modulation of TTX-sensitive voltage-dependent Na(+ )channels by β-bungarotoxin in rat cerebellar neurons
por: Guo, Da, et al.
Publicado: (2012)

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis
por: Peng, Huiming, et al.
Publicado: (2015)

Acid sphingomyelinase promotes SGK1-dependent vascular calcification
por: Luong, Trang Thi Doan, et al.
Publicado: (2021)

Neutral ceramidase is a marker for cognitive performance in rats and monkeys
por: Kalinichenko, Liubov S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q90le55e5avr43ouhbpnmdesgr