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Antibody Repertoires in Humanized NOD-scid-IL2Rγ(null) Mice and Human B Cells Reveals Human-Like Diversification and Tolerance Checkpoints in the Mouse

Immunodeficient mice reconstituted with human hematopoietic stem cells enable the in vivo study of human hematopoiesis. In particular, NOD-scid-IL2Rγ(null) engrafted mice have been shown to have reasonable levels of T and B cell repopulation and can mount T-cell dependent responses; however, antigen...

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Detalles Bibliográficos
Autores principales:	Ippolito, Gregory C., Hoi, Kam Hon, Reddy, Sai T., Carroll, Sean M., Ge, Xin, Rogosch, Tobias, Zemlin, Michael, Shultz, Leonard D., Ellington, Andrew D., VanDenBerg, Carla L., Georgiou, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338711/ https://www.ncbi.nlm.nih.gov/pubmed/22558161 http://dx.doi.org/10.1371/journal.pone.0035497

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