Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation

Receptor tyrosine kinase signaling cooperates with WNT/β-catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/β-catenin by FGFR2, FGFR3, EGFR and TRKA kinases, which is independent of the PI3K...

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Detalles Bibliográficos
Autores principales: Krejci, Pavel, Aklian, Anie, Kaucka, Marketa, Sevcikova, Eva, Prochazkova, Jirina, Masek, Jan Kukla, Mikolka, Pavol, Pospisilova, Tereza, Spoustova, Tereza, Weis, MaryAnn, Paznekas, William A., Wolf, Joshua H., Gutkind, J. Silvio, Wilcox, William R., Kozubik, Alois, Jabs, Ethylin Wang, Bryja, Vitezslav, Salazar, Lisa, Vesela, Iva, Balek, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338780/
https://www.ncbi.nlm.nih.gov/pubmed/22558232
http://dx.doi.org/10.1371/journal.pone.0035826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338780/
https://www.ncbi.nlm.nih.gov/pubmed/22558232
http://dx.doi.org/10.1371/journal.pone.0035826

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