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New Details of HCV NS3/4A Proteinase Functionality Revealed by a High-Throughput Cleavage Assay

BACKGROUND: The hepatitis C virus (HCV) genome encodes a long polyprotein, which is processed by host cell and viral proteases to the individual structural and non-structural (NS) proteins. HCV NS3/4A serine proteinase (NS3/4A) is a non-covalent heterodimer of the N-terminal, ∼180-residue portion of...

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Detalles Bibliográficos
Autores principales:	Shiryaev, Sergey A., Thomsen, Elliot R., Cieplak, Piotr, Chudin, Eugene, Cheltsov, Anton V., Chee, Mark S., Kozlov, Igor A., Strongin, Alex Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338790/ https://www.ncbi.nlm.nih.gov/pubmed/22558217 http://dx.doi.org/10.1371/journal.pone.0035759

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