Cargando…
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Bone mineral density (BMD) is the most important predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and East Asian ancestry. We tested the top-associated BMD...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338864/ https://www.ncbi.nlm.nih.gov/pubmed/22504420 http://dx.doi.org/10.1038/ng.2249 |
| _version_ | 1782231279530409984 |
|---|---|
| author | Estrada, Karol Styrkarsdottir, Unnur Evangelou, Evangelos Hsu, Yi-Hsiang Duncan, Emma L Ntzani, Evangelia E Oei, Ling Albagha, Omar M E Amin, Najaf Kemp, John P Koller, Daniel L Li, Guo Liu, Ching-Ti Minster, Ryan L Moayyeri, Alireza Vandenput, Liesbeth Willner, Dana Xiao, Su-Mei Yerges-Armstrong, Laura M Zheng, Hou-Feng Alonso, Nerea Eriksson, Joel Kammerer, Candace M Kaptoge, Stephen K Leo, Paul J Thorleifsson, Gudmar Wilson, Scott G Wilson, James F Aalto, Ville Alen, Markku Aragaki, Aaron K Aspelund, Thor Center, Jacqueline R Dailiana, Zoe Duggan, David J Garcia, Melissa Garcia-Giralt, Natàlia Giroux, Sylvie Hallmans, Göran Hocking, Lynne J Husted, Lise Bjerre Jameson, Karen A Khusainova, Rita Kim, Ghi Su Kooperberg, Charles Koromila, Theodora Kruk, Marcin Laaksonen, Marika Lacroix, Andrea Z Lee, Seung Hun Leung, Ping C Lewis, Joshua R Masi, Laura Mencej-Bedrac, Simona Nguyen, Tuan V Nogues, Xavier Patel, Millan S Prezelj, Janez Rose, Lynda M Scollen, Serena Siggeirsdottir, Kristin Smith, Albert V Svensson, Olle Trompet, Stella Trummer, Olivia van Schoor, Natasja M Woo, Jean Zhu, Kun Balcells, Susana Brandi, Maria Luisa Buckley, Brendan M Cheng, Sulin Christiansen, Claus Cooper, Cyrus Dedoussis, George Ford, Ian Frost, Morten Goltzman, David González-Macías, Jesús Kähönen, Mika Karlsson, Magnus Khusnutdinova, Elza Koh, Jung-Min Kollia, Panagoula Langdahl, Bente Lomholt Leslie, William D Lips, Paul Ljunggren, Östen Lorenc, Roman S Marc, Janja Mellström, Dan Obermayer-Pietsch, Barbara Olmos, José M Pettersson-Kymmer, Ulrika Reid, David M Riancho, José A Ridker, Paul M Rousseau, François Slagboom, P Eline Tang, Nelson LS Urreizti, Roser Van Hul, Wim Viikari, Jorma Zarrabeitia, María T Aulchenko, Yurii S Castano-Betancourt, Martha Grundberg, Elin Herrera, Lizbeth Ingvarsson, Thorvaldur Johannsdottir, Hrefna Kwan, Tony Li, Rui Luben, Robert Medina-Gómez, Carolina Palsson, Stefan Th Reppe, Sjur Rotter, Jerome I Sigurdsson, Gunnar van Meurs, Joyce B J Verlaan, Dominique Williams, Frances MK Wood, Andrew R Zhou, Yanhua Gautvik, Kaare M Pastinen, Tomi Raychaudhuri, Soumya Cauley, Jane A Chasman, Daniel I Clark, Graeme R Cummings, Steven R Danoy, Patrick Dennison, Elaine M Eastell, Richard Eisman, John A Gudnason, Vilmundur Hofman, Albert Jackson, Rebecca D Jones, Graeme Jukema, J Wouter Khaw, Kay-Tee Lehtimäki, Terho Liu, Yongmei Lorentzon, Mattias McCloskey, Eugene Mitchell, Braxton D Nandakumar, Kannabiran Nicholson, Geoffrey C Oostra, Ben A Peacock, Munro Pols, Huibert A P Prince, Richard L Raitakari, Olli Reid, Ian R Robbins, John Sambrook, Philip N Sham, Pak Chung Shuldiner, Alan R Tylavsky, Frances A van Duijn, Cornelia M Wareham, Nick J Cupples, L Adrienne Econs, Michael J Evans, David M Harris, Tamara B Kung, Annie Wai Chee Psaty, Bruce M Reeve, Jonathan Spector, Timothy D Streeten, Elizabeth A Zillikens, M Carola Thorsteinsdottir, Unnur Ohlsson, Claes Karasik, David Richards, J Brent Brown, Matthew A Stefansson, Kari Uitterlinden, André G Ralston, Stuart H Ioannidis, John P A Kiel, Douglas P Rivadeneira, Fernando |
| author_facet | Estrada, Karol Styrkarsdottir, Unnur Evangelou, Evangelos Hsu, Yi-Hsiang Duncan, Emma L Ntzani, Evangelia E Oei, Ling Albagha, Omar M E Amin, Najaf Kemp, John P Koller, Daniel L Li, Guo Liu, Ching-Ti Minster, Ryan L Moayyeri, Alireza Vandenput, Liesbeth Willner, Dana Xiao, Su-Mei Yerges-Armstrong, Laura M Zheng, Hou-Feng Alonso, Nerea Eriksson, Joel Kammerer, Candace M Kaptoge, Stephen K Leo, Paul J Thorleifsson, Gudmar Wilson, Scott G Wilson, James F Aalto, Ville Alen, Markku Aragaki, Aaron K Aspelund, Thor Center, Jacqueline R Dailiana, Zoe Duggan, David J Garcia, Melissa Garcia-Giralt, Natàlia Giroux, Sylvie Hallmans, Göran Hocking, Lynne J Husted, Lise Bjerre Jameson, Karen A Khusainova, Rita Kim, Ghi Su Kooperberg, Charles Koromila, Theodora Kruk, Marcin Laaksonen, Marika Lacroix, Andrea Z Lee, Seung Hun Leung, Ping C Lewis, Joshua R Masi, Laura Mencej-Bedrac, Simona Nguyen, Tuan V Nogues, Xavier Patel, Millan S Prezelj, Janez Rose, Lynda M Scollen, Serena Siggeirsdottir, Kristin Smith, Albert V Svensson, Olle Trompet, Stella Trummer, Olivia van Schoor, Natasja M Woo, Jean Zhu, Kun Balcells, Susana Brandi, Maria Luisa Buckley, Brendan M Cheng, Sulin Christiansen, Claus Cooper, Cyrus Dedoussis, George Ford, Ian Frost, Morten Goltzman, David González-Macías, Jesús Kähönen, Mika Karlsson, Magnus Khusnutdinova, Elza Koh, Jung-Min Kollia, Panagoula Langdahl, Bente Lomholt Leslie, William D Lips, Paul Ljunggren, Östen Lorenc, Roman S Marc, Janja Mellström, Dan Obermayer-Pietsch, Barbara Olmos, José M Pettersson-Kymmer, Ulrika Reid, David M Riancho, José A Ridker, Paul M Rousseau, François Slagboom, P Eline Tang, Nelson LS Urreizti, Roser Van Hul, Wim Viikari, Jorma Zarrabeitia, María T Aulchenko, Yurii S Castano-Betancourt, Martha Grundberg, Elin Herrera, Lizbeth Ingvarsson, Thorvaldur Johannsdottir, Hrefna Kwan, Tony Li, Rui Luben, Robert Medina-Gómez, Carolina Palsson, Stefan Th Reppe, Sjur Rotter, Jerome I Sigurdsson, Gunnar van Meurs, Joyce B J Verlaan, Dominique Williams, Frances MK Wood, Andrew R Zhou, Yanhua Gautvik, Kaare M Pastinen, Tomi Raychaudhuri, Soumya Cauley, Jane A Chasman, Daniel I Clark, Graeme R Cummings, Steven R Danoy, Patrick Dennison, Elaine M Eastell, Richard Eisman, John A Gudnason, Vilmundur Hofman, Albert Jackson, Rebecca D Jones, Graeme Jukema, J Wouter Khaw, Kay-Tee Lehtimäki, Terho Liu, Yongmei Lorentzon, Mattias McCloskey, Eugene Mitchell, Braxton D Nandakumar, Kannabiran Nicholson, Geoffrey C Oostra, Ben A Peacock, Munro Pols, Huibert A P Prince, Richard L Raitakari, Olli Reid, Ian R Robbins, John Sambrook, Philip N Sham, Pak Chung Shuldiner, Alan R Tylavsky, Frances A van Duijn, Cornelia M Wareham, Nick J Cupples, L Adrienne Econs, Michael J Evans, David M Harris, Tamara B Kung, Annie Wai Chee Psaty, Bruce M Reeve, Jonathan Spector, Timothy D Streeten, Elizabeth A Zillikens, M Carola Thorsteinsdottir, Unnur Ohlsson, Claes Karasik, David Richards, J Brent Brown, Matthew A Stefansson, Kari Uitterlinden, André G Ralston, Stuart H Ioannidis, John P A Kiel, Douglas P Rivadeneira, Fernando |
| author_sort | Estrada, Karol |
| collection | PubMed |
| description | Bone mineral density (BMD) is the most important predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and East Asian ancestry. We tested the top-associated BMD markers for replication in 50,933 independent subjects and for risk of low-trauma fracture in 31,016 cases and 102,444 controls. We identified 56 loci (32 novel)associated with BMD atgenome-wide significant level (P<5×10(−8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal-stem-cell differentiation, endochondral ossification and the Wnt signalling pathways. However, we also discovered loci containing genes not known to play a role in bone biology. Fourteen BMD loci were also associated with fracture risk (P<5×10(−4), Bonferroni corrected), of which six reached P<5×10(−8) including: 18p11.21 (C18orf19), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. |
| format | Online Article Text |
| id | pubmed-3338864 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33388642012-11-01 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture Estrada, Karol Styrkarsdottir, Unnur Evangelou, Evangelos Hsu, Yi-Hsiang Duncan, Emma L Ntzani, Evangelia E Oei, Ling Albagha, Omar M E Amin, Najaf Kemp, John P Koller, Daniel L Li, Guo Liu, Ching-Ti Minster, Ryan L Moayyeri, Alireza Vandenput, Liesbeth Willner, Dana Xiao, Su-Mei Yerges-Armstrong, Laura M Zheng, Hou-Feng Alonso, Nerea Eriksson, Joel Kammerer, Candace M Kaptoge, Stephen K Leo, Paul J Thorleifsson, Gudmar Wilson, Scott G Wilson, James F Aalto, Ville Alen, Markku Aragaki, Aaron K Aspelund, Thor Center, Jacqueline R Dailiana, Zoe Duggan, David J Garcia, Melissa Garcia-Giralt, Natàlia Giroux, Sylvie Hallmans, Göran Hocking, Lynne J Husted, Lise Bjerre Jameson, Karen A Khusainova, Rita Kim, Ghi Su Kooperberg, Charles Koromila, Theodora Kruk, Marcin Laaksonen, Marika Lacroix, Andrea Z Lee, Seung Hun Leung, Ping C Lewis, Joshua R Masi, Laura Mencej-Bedrac, Simona Nguyen, Tuan V Nogues, Xavier Patel, Millan S Prezelj, Janez Rose, Lynda M Scollen, Serena Siggeirsdottir, Kristin Smith, Albert V Svensson, Olle Trompet, Stella Trummer, Olivia van Schoor, Natasja M Woo, Jean Zhu, Kun Balcells, Susana Brandi, Maria Luisa Buckley, Brendan M Cheng, Sulin Christiansen, Claus Cooper, Cyrus Dedoussis, George Ford, Ian Frost, Morten Goltzman, David González-Macías, Jesús Kähönen, Mika Karlsson, Magnus Khusnutdinova, Elza Koh, Jung-Min Kollia, Panagoula Langdahl, Bente Lomholt Leslie, William D Lips, Paul Ljunggren, Östen Lorenc, Roman S Marc, Janja Mellström, Dan Obermayer-Pietsch, Barbara Olmos, José M Pettersson-Kymmer, Ulrika Reid, David M Riancho, José A Ridker, Paul M Rousseau, François Slagboom, P Eline Tang, Nelson LS Urreizti, Roser Van Hul, Wim Viikari, Jorma Zarrabeitia, María T Aulchenko, Yurii S Castano-Betancourt, Martha Grundberg, Elin Herrera, Lizbeth Ingvarsson, Thorvaldur Johannsdottir, Hrefna Kwan, Tony Li, Rui Luben, Robert Medina-Gómez, Carolina Palsson, Stefan Th Reppe, Sjur Rotter, Jerome I Sigurdsson, Gunnar van Meurs, Joyce B J Verlaan, Dominique Williams, Frances MK Wood, Andrew R Zhou, Yanhua Gautvik, Kaare M Pastinen, Tomi Raychaudhuri, Soumya Cauley, Jane A Chasman, Daniel I Clark, Graeme R Cummings, Steven R Danoy, Patrick Dennison, Elaine M Eastell, Richard Eisman, John A Gudnason, Vilmundur Hofman, Albert Jackson, Rebecca D Jones, Graeme Jukema, J Wouter Khaw, Kay-Tee Lehtimäki, Terho Liu, Yongmei Lorentzon, Mattias McCloskey, Eugene Mitchell, Braxton D Nandakumar, Kannabiran Nicholson, Geoffrey C Oostra, Ben A Peacock, Munro Pols, Huibert A P Prince, Richard L Raitakari, Olli Reid, Ian R Robbins, John Sambrook, Philip N Sham, Pak Chung Shuldiner, Alan R Tylavsky, Frances A van Duijn, Cornelia M Wareham, Nick J Cupples, L Adrienne Econs, Michael J Evans, David M Harris, Tamara B Kung, Annie Wai Chee Psaty, Bruce M Reeve, Jonathan Spector, Timothy D Streeten, Elizabeth A Zillikens, M Carola Thorsteinsdottir, Unnur Ohlsson, Claes Karasik, David Richards, J Brent Brown, Matthew A Stefansson, Kari Uitterlinden, André G Ralston, Stuart H Ioannidis, John P A Kiel, Douglas P Rivadeneira, Fernando Nat Genet Article Bone mineral density (BMD) is the most important predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and East Asian ancestry. We tested the top-associated BMD markers for replication in 50,933 independent subjects and for risk of low-trauma fracture in 31,016 cases and 102,444 controls. We identified 56 loci (32 novel)associated with BMD atgenome-wide significant level (P<5×10(−8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal-stem-cell differentiation, endochondral ossification and the Wnt signalling pathways. However, we also discovered loci containing genes not known to play a role in bone biology. Fourteen BMD loci were also associated with fracture risk (P<5×10(−4), Bonferroni corrected), of which six reached P<5×10(−8) including: 18p11.21 (C18orf19), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. 2012-04-15 /pmc/articles/PMC3338864/ /pubmed/22504420 http://dx.doi.org/10.1038/ng.2249 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Estrada, Karol Styrkarsdottir, Unnur Evangelou, Evangelos Hsu, Yi-Hsiang Duncan, Emma L Ntzani, Evangelia E Oei, Ling Albagha, Omar M E Amin, Najaf Kemp, John P Koller, Daniel L Li, Guo Liu, Ching-Ti Minster, Ryan L Moayyeri, Alireza Vandenput, Liesbeth Willner, Dana Xiao, Su-Mei Yerges-Armstrong, Laura M Zheng, Hou-Feng Alonso, Nerea Eriksson, Joel Kammerer, Candace M Kaptoge, Stephen K Leo, Paul J Thorleifsson, Gudmar Wilson, Scott G Wilson, James F Aalto, Ville Alen, Markku Aragaki, Aaron K Aspelund, Thor Center, Jacqueline R Dailiana, Zoe Duggan, David J Garcia, Melissa Garcia-Giralt, Natàlia Giroux, Sylvie Hallmans, Göran Hocking, Lynne J Husted, Lise Bjerre Jameson, Karen A Khusainova, Rita Kim, Ghi Su Kooperberg, Charles Koromila, Theodora Kruk, Marcin Laaksonen, Marika Lacroix, Andrea Z Lee, Seung Hun Leung, Ping C Lewis, Joshua R Masi, Laura Mencej-Bedrac, Simona Nguyen, Tuan V Nogues, Xavier Patel, Millan S Prezelj, Janez Rose, Lynda M Scollen, Serena Siggeirsdottir, Kristin Smith, Albert V Svensson, Olle Trompet, Stella Trummer, Olivia van Schoor, Natasja M Woo, Jean Zhu, Kun Balcells, Susana Brandi, Maria Luisa Buckley, Brendan M Cheng, Sulin Christiansen, Claus Cooper, Cyrus Dedoussis, George Ford, Ian Frost, Morten Goltzman, David González-Macías, Jesús Kähönen, Mika Karlsson, Magnus Khusnutdinova, Elza Koh, Jung-Min Kollia, Panagoula Langdahl, Bente Lomholt Leslie, William D Lips, Paul Ljunggren, Östen Lorenc, Roman S Marc, Janja Mellström, Dan Obermayer-Pietsch, Barbara Olmos, José M Pettersson-Kymmer, Ulrika Reid, David M Riancho, José A Ridker, Paul M Rousseau, François Slagboom, P Eline Tang, Nelson LS Urreizti, Roser Van Hul, Wim Viikari, Jorma Zarrabeitia, María T Aulchenko, Yurii S Castano-Betancourt, Martha Grundberg, Elin Herrera, Lizbeth Ingvarsson, Thorvaldur Johannsdottir, Hrefna Kwan, Tony Li, Rui Luben, Robert Medina-Gómez, Carolina Palsson, Stefan Th Reppe, Sjur Rotter, Jerome I Sigurdsson, Gunnar van Meurs, Joyce B J Verlaan, Dominique Williams, Frances MK Wood, Andrew R Zhou, Yanhua Gautvik, Kaare M Pastinen, Tomi Raychaudhuri, Soumya Cauley, Jane A Chasman, Daniel I Clark, Graeme R Cummings, Steven R Danoy, Patrick Dennison, Elaine M Eastell, Richard Eisman, John A Gudnason, Vilmundur Hofman, Albert Jackson, Rebecca D Jones, Graeme Jukema, J Wouter Khaw, Kay-Tee Lehtimäki, Terho Liu, Yongmei Lorentzon, Mattias McCloskey, Eugene Mitchell, Braxton D Nandakumar, Kannabiran Nicholson, Geoffrey C Oostra, Ben A Peacock, Munro Pols, Huibert A P Prince, Richard L Raitakari, Olli Reid, Ian R Robbins, John Sambrook, Philip N Sham, Pak Chung Shuldiner, Alan R Tylavsky, Frances A van Duijn, Cornelia M Wareham, Nick J Cupples, L Adrienne Econs, Michael J Evans, David M Harris, Tamara B Kung, Annie Wai Chee Psaty, Bruce M Reeve, Jonathan Spector, Timothy D Streeten, Elizabeth A Zillikens, M Carola Thorsteinsdottir, Unnur Ohlsson, Claes Karasik, David Richards, J Brent Brown, Matthew A Stefansson, Kari Uitterlinden, André G Ralston, Stuart H Ioannidis, John P A Kiel, Douglas P Rivadeneira, Fernando Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture |
| title | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture |
| title_full | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture |
| title_fullStr | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture |
| title_full_unstemmed | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture |
| title_short | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture |
| title_sort | genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338864/ https://www.ncbi.nlm.nih.gov/pubmed/22504420 http://dx.doi.org/10.1038/ng.2249 |
| work_keys_str_mv | AT estradakarol genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT styrkarsdottirunnur genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT evangelouevangelos genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT hsuyihsiang genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT duncanemmal genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT ntzanievangeliae genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT oeiling genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT albaghaomarme genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT aminnajaf genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kempjohnp genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kollerdaniell genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT liguo genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT liuchingti genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT minsterryanl genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT moayyerialireza genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT vandenputliesbeth genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT willnerdana genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT xiaosumei genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT yergesarmstronglauram genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT zhenghoufeng genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT alonsonerea genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT erikssonjoel genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kammerercandacem genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kaptogestephenk genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT leopaulj genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT thorleifssongudmar genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT wilsonscottg genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT wilsonjamesf genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT aaltoville genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT alenmarkku genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT aragakiaaronk genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT aspelundthor genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT centerjacqueliner genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT dailianazoe genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT duggandavidj genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT garciamelissa genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT garciagiraltnatalia genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT girouxsylvie genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT hallmansgoran genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT hockinglynnej genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT hustedlisebjerre genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT jamesonkarena genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT khusainovarita genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kimghisu genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kooperbergcharles genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT koromilatheodora genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT krukmarcin genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT laaksonenmarika genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lacroixandreaz genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT leeseunghun genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT leungpingc genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lewisjoshuar genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT masilaura genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT mencejbedracsimona genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT nguyentuanv genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT noguesxavier genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT patelmillans genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT prezeljjanez genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT roselyndam genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT scollenserena genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT siggeirsdottirkristin genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT smithalbertv genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT svenssonolle genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT trompetstella genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT trummerolivia genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT vanschoornatasjam genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT woojean genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT zhukun genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT balcellssusana genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT brandimarialuisa genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT buckleybrendanm genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT chengsulin genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT christiansenclaus genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT coopercyrus genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT dedoussisgeorge genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT fordian genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT frostmorten genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT goltzmandavid genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT gonzalezmaciasjesus genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kahonenmika genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT karlssonmagnus genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT khusnutdinovaelza genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kohjungmin genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kolliapanagoula genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT langdahlbentelomholt genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lesliewilliamd genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lipspaul genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT ljunggrenosten genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lorencromans genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT marcjanja genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT mellstromdan genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT obermayerpietschbarbara genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT olmosjosem genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT petterssonkymmerulrika genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT reiddavidm genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT rianchojosea genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT ridkerpaulm genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT rousseaufrancois genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT slagboompeline genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT tangnelsonls genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT urreiztiroser genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT vanhulwim genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT viikarijorma genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT zarrabeitiamariat genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT aulchenkoyuriis genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT castanobetancourtmartha genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT grundbergelin genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT herreralizbeth genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT ingvarssonthorvaldur genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT johannsdottirhrefna genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kwantony genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lirui genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lubenrobert genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT medinagomezcarolina genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT palssonstefanth genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT reppesjur genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT rotterjeromei genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT sigurdssongunnar genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT vanmeursjoycebj genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT verlaandominique genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT williamsfrancesmk genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT woodandrewr genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT zhouyanhua genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT gautvikkaarem genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT pastinentomi genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT raychaudhurisoumya genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT cauleyjanea genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT chasmandanieli genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT clarkgraemer genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT cummingsstevenr genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT danoypatrick genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT dennisonelainem genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT eastellrichard genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT eismanjohna genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT gudnasonvilmundur genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT hofmanalbert genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT jacksonrebeccad genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT jonesgraeme genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT jukemajwouter genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT khawkaytee genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lehtimakiterho genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT liuyongmei genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT lorentzonmattias genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT mccloskeyeugene genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT mitchellbraxtond genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT nandakumarkannabiran genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT nicholsongeoffreyc genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT oostrabena genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT peacockmunro genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT polshuibertap genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT princerichardl genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT raitakariolli genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT reidianr genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT robbinsjohn genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT sambrookphilipn genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT shampakchung genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT shuldineralanr genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT tylavskyfrancesa genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT vanduijncorneliam genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT warehamnickj genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT cupplesladrienne genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT econsmichaelj genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT evansdavidm genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT harristamarab genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kunganniewaichee genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT psatybrucem genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT reevejonathan genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT spectortimothyd genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT streetenelizabetha genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT zillikensmcarola genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT thorsteinsdottirunnur genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT ohlssonclaes genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT karasikdavid genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT richardsjbrent genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT brownmatthewa genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT stefanssonkari genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT uitterlindenandreg genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT ralstonstuarth genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT ioannidisjohnpa genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT kieldouglasp genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture AT rivadeneirafernando genomewidemetaanalysisidentifies56bonemineraldensitylociandreveals14lociassociatedwithriskoffracture |